Publications scientifiques récentes rédigées par des chercheurs sur les cellules souches et la médecine régénérative

OCTOBRE

Co-Delivery of Sustained Release Chondroitinase ABC-37 With Human iPSC-Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke.
Letko Khait N, Li DX, Guo K, Cui H, Sirianni Q, Abdo D, Morshead CM, Shoichet MS. Adv Sci (Weinh). 2026 Sep 9:e22499. doi: 10.1002/advs.202522499. Online ahead of print.PMID: 42717514 Free PMC article.

HOPX regulates the development and lineage progression of human stem cell-derived outer radial glia-like cells.
Dong XX, Choi WWY, Ahmed M, Nishimura H, Tian A, Millar D, Bhattacharya A, Aggarwal A, Vu L, Weng OY, Nguyen R, Chakraborty P, Wang LY, Wilson MD, Shu Q, Li X, Wu YC, Muffat J, Li Y. Stem Cell Reports. 2026 Sep 24:103087. doi: 10.1016/j.stemcr.2026.103087. Online ahead of print.PMID: 42785308 Free article.

Protocol for mechanical nuclei dissociation and isolation from frozen tissue and organoids for single-nucleus RNA sequencing.
Guillon M, Brin M, Laurent L, Flamier A. STAR Protoc. 2026 Sep 28;7(4):104855. doi: 10.1016/j.xpro.2026.104855. Online ahead of print.PMID: 42804364 Free article.

The Shifting Landscape of Natural Health Product Licensing in Canada: The e-Commerce Case of Stem Cell Supplements.
Marcon AR, Jewer M, Caulfield T. Interact J Med Res. 2026 Sep 28;15:e86747. doi: 10.2196/86747.PMID: 42804752 Free PMC article.

Microscale strategies in engineering the pancreas: Toward clinical translation.
Billaud M, Campbell BE, Zhu X, Ling SD, Movasat H, Li C, Prezelj D, Vdovenko D, Shakiba N, Hoesli CA, Moraes C. Adv Drug Deliv Rev. 2026 Sep;236:115919. doi: 10.1016/j.addr.2026.115919. Epub 2026 Jun 16.PMID: 42303158 Free article. Review

IFN-γ drives long-term bone marrow niche dysfunction following doxorubicin-based chemotherapy.
Li X, Aguilar-Navarro AG, Nader M, Jahangiri S, Lee HS, Edun G, Gower M, Yang D, Fernandez M, Lin B, Oh D, Farhat S, Phillips DM, Bartman S, Murray D, Kaszuba C, Kossinna P, Kamath M, Whyne C, Schwartz G, Bajaj J, Kislinger T, Zhou BO, Coutu D, Akens M, Changoor A, Mallevaey T, Gaiti F, Jones C, Naik S, Minden M, Arruda A, Hitzler J, Lee KJ, Kim YM, Adams RH, Sivara KK, Tikhonova AN. Blood. 2026 Sep 3;148(10):1277-1291. doi: 10.1182/blood.2025030946.PMID: 42008378

Therapeutic strategies targeting muscle stem cells in satellite cell-opathies.
Garcia P, Mokhtari I, Dumont NA. J Neuromuscul Dis. 2026 Sep;13(5):875-897. doi: 10.1177/22143602251414570. Epub 2026 Feb 19.PMID: 41712369 Free PMC article. Review.

Metabolic Programming of β-Cell Fate, State, and Function through Time and Space.
MacDonald TL, Bonner-Weir S. Physiology (Bethesda). 2026 Sep 1;41(5):0. doi: 10.1152/physiol.00049.2025. Epub 2026 Jan 16.PMID: 41543436 Free PMC article. Review.

Cilia beating of ependymal cells regulates adult neural stem cell quiescence via mechanical forces mediated by PKD1/2-TRPM3.
Bressan C, Gengatharan A, Rodriguez-Aller R, Richter ML, Snapyan M, Fischer-Sternjak J, Roukerd MR, Rosin N, Cherinet A, Biernaskie J, Habibi E, Götz M, Saghatelyan A. Neuron. 2026 Sep 2;114(17):3251-3266.e7. doi: 10.1016/j.neuron.2026.04.031. Epub 2026 May 13.PMID: 42134321

Guiding the spatial organization of engineered heart tissues.
Beeghly GF, Shakeri A, Mirzapour-Shafiyi F, Dikyol C, Offen N, Alsaafin A, Nuber UA, Radisic M. Adv Drug Deliv Rev. 2026 Sep;236:115907. doi: 10.1016/j.addr.2026.115907. Epub 2026 Jun 1.PMID: 42225208 Free article. Review

The comparative cell physiology of stem cell-derived and primary human β cells.
Maghera J, Chu CMJ, Schaaf C, Bruin JE, Johnson JD, Lynn FC, MacDonald PE. Nat Rev Endocrinol. 2026 Sep 4. doi: 10.1038/s41574-026-01295-0. Online ahead of print.PMID: 42697977 Review.

Microfluidics in heart-on-a-chip platforms for cardiovascular drug discovery and cardiotoxicity assessment.
Dikyol C, Alsaafin A, Bodenstein DF, Beeghly GF, Popovic AM, Jiang R, Radisic M. Adv Drug Deliv Rev. 2026 Sep 5;239:115972. doi: 10.1016/j.addr.2026.115972. Online ahead of print.PMID: 42700845 Free article. Review.

Do Stimulants Promote Arrhythmic Risk: Insights From a Human-Induced Pluripotent Stem Cell-Derived Cardiomyocyte Model.
Arslanova A, Wong S, Franciosi S, Tibbits GF, Prondzynski M, Sanatani S. J Arrhythm. 2026 Sep 24;42(5):e70479. doi: 10.1002/joa3.70479. eCollection 2026 Oct.PMID: 42798728 Free PMC article.

Lineage relationships in muscle stem cells: linking functional fate to molecular state.
Ashekyan O, Catenacci MJ, Guilhot C, Lin T, Rudnicki MA. Front Cell Dev Biol. 2026 Sep 11;14:1930884. doi: 10.3389/fcell.2026.1930884. eCollection 2026.PMID: 42798658 Free PMC article. Review.

De novo formation of human sebaceous glands using self-assembled skin substitutes.
Magne B, Cattier B, Lemire-Rondeau M, Morissette A, Larouche D, Philippe É, Germain L. J Invest Dermatol. 2026 Sep;146(9):2430-2438.e4. doi: 10.1016/j.jid.2026.03.021. Epub 2026 Apr 1.PMID: 41933878 Free article.

Evaluating and comparing the signalling and functional landscape of hiPSC-CMs derived from patients with dilated cardiomyopathy.
Castagnola G, Loggia D, Bourque K, Alim K, Derish I, Rody E, Gryz Z, Hawey C, Jones-Tabah J, Bhardwaj A, Mouttet L, Gendron N, Giannetti N, Cecere R, Hui SK, Hébert TE. NPJ Biomed Innov. 2026 Sep 11;3(1):55. doi: 10.1038/s44385-026-00111-8.PMID: 42728314 Free PMC article.

Immature Neutrophil Programs Associate With Burn Mortality and Extend Across Critical Illnesses.
Sinha S, Mandujano-Tinoco EA, Kutluberk E, Mulder PPG, Collao N, Chockalingam K, Pun A, Dardari R, Verly M, Fraulin FOG, Harrop AR, Rosin NL, Gabriel V, Biernaskie J. J Burn Care Res. 2026 Sep 8;47(5):1445-1459. doi: 10.1093/jbcr/irag067.PMID: 42053371

Rapid Generation of Functional Oligodendrocytes From Human Induced Pluripotent Stem Cells Through Small Molecule Guided Differentiation.
Bienjonetti I, Roy V, Beaudet MJ, Louit A, Martineau L, Berthod F, Dupré N, Gros-Louis F. J Neurosci Res. 2026 Sep;104(9):e70155. doi: 10.1002/jnr.70155.PMID: 42703009 Free PMC article.

Beyond immunity: macrophage plasticity in vascular regeneration.
Huo ST, Inoue T, Robbins CS, Nunes SS. NPJ Biomed Innov. 2026 Sep 24;3(1):58. doi: 10.1038/s44385-026-00114-5.PMID: 42786206 Free PMC article. Review.

Generation of a patient-derived iPSC line from a clinically diagnosed MELAS case carrying the mtDNA m.3243A > G variant.
Sharma G, Srivastava A, Rockman-Greenberg C, Dhingra S. Stem Cell Res. 2026 Sep;95:104038. doi: 10.1016/j.scr.2026.104038. Epub 2026 Jun 18.PMID: 42320428 Free article.

Targeted cell deposition for lung re-endothelialization.
Chan JKD, Chadwick EA, Taniguchi D, Ahmadipour M, Suzuki T, Romero D, Amon C, Waddell TK, Karoubi G, Bazylak A. Biomech Model Mechanobiol. 2026 Sep 27;25(5):113. doi: 10.1007/s10237-026-02129-8.PMID: 42801342 Free PMC article.

Angiogenesis-promoting properties of phosphorylcholine mimetic nanoparticles.
Moradi M, Poudel BK, Hooker E, Aghajanzadeh-Kiyaseh M, Rusu D, Griffith M, Larrivée B. Angiogenesis. 2026 Sep 23;29(4):71. doi: 10.1007/s10456-026-10094-0.PMID: 42776284

SEPTEMBRE

Responders vs. non-responders to mesenchymal stromal cells in knee osteoarthritis: Mechanistic correlates of donor cell and patient features.
Robb KP, Rabani R, Vohra S, Singh S, Chahal J, Audet J, Perruccio AV, Naraghi A, Gandhi R, Espin-Garcia O, Viswanathan S.Stem Cell Reports. 2026 Aug 6:103024. doi: 10.1016/j.stemcr.2026.103024. Online ahead of print.PMID: 42561945 Free article.

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius).
Noble AI, Payne SL, Vickaryous MK.Dev Dyn. 2026 Aug 19. doi: 10.1002/dvdy.70181. Online ahead of print.PMID: 42615433

Alignment of registered cell therapy trial protocols with regulatory guidance on preclinical evidence: a systematic, cross-sectional, protocol-level analysis.
Jeffers MS, Tangamornsuksan W, Dorus B, Bedford P, Kimmelman J, McIsaac DI, Fergusson DA, Lalu MM.EBioMedicine. 2026 Aug 28;131:106456. doi: 10.1016/j.ebiom.2026.106456. Online ahead of print.PMID: 42664603 Free article.

Heart-on-a-chip and vasculature-on-a-chip platforms as models of cardiovascular disease.
Khosravi R, Radisic M.Nat Rev Cardiol. 2026 Aug;23(8):537-554. doi: 10.1038/s41569-026-01255-1. Epub 2026 Feb 11.PMID: 41673471 Review.

iPSC generation from PBMCs of a MELAS patient for mitochondrial dysfunction studies.
Sharma G, Srivastava A, Rockman-Greenberg C, Dhingra S.Stem Cell Res. 2026 Aug;94:103992. doi: 10.1016/j.scr.2026.103992. Epub 2026 Apr 16.PMID: 42024990 Free article. 

Engineering human T cells with antigen receptors for immune regulation in autoimmune disease and transplantation.
Mangat S, Tuomela K, Levings MK.Mol Ther. 2026 Aug 5;34(8):4407-4421. doi: 10.1016/j.ymthe.2026.05.017. Epub 2026 May 26.PMID: 42198842 Review.

Nanofibrous Bioabsorbable Functionalized Scaffolds Augment Subcutaneous Islet Engraftment and Function in Mice.
Kuppan P, Castro C, Paramor J, Waduthanthri KD, Cuesta-Gomez N, Bose A, Ma I, Rosko M, Pepper AR, Korbutt GS.Diabetes. 2026 Aug 1;75(8):1424-1436. doi: 10.2337/db26-0149.PMID: 42240469

Extracellular vesicles in patients affected by burns: Unraveling clinical, immunological, and therapeutic dimensions.
Caya R, Mareux E, Arif S, Moulin VJ.Burns. 2026 Aug;52(6):107984. doi: 10.1016/j.burns.2026.107984. Epub 2026 Mar 25.PMID: 42134105 Free article. Review.

Prime Editing Mediated Generation and Correction of the mdx5cv Mutation Restores Dystrophin Expression in Myoblasts.
Siddika A, Husseiny FE, Rousseau J, Tremblay JP.Int J Mol Sci. 2026 Aug 1;27(15):6927. doi: 10.3390/ijms27156927.PMID: 42589580 Free PMC article.

Serum-Free Expanded Hair Follicle Mesenchymal Stem Cells Promote Cartilage Repair in a Murine Full-Thickness Defect Model.
Sun H, Gysel E, Larijani L, Young D, Dufour A, Fayyad M, Fatehi A, Ahmed N, Shah T, Kallos MS, Taylor D, Krawetz RJ.Transplant Cell Ther. 2026 Aug 4:S2666-6367(26)00592-0. doi: 10.1016/j.jtct.2026.07.030. Online ahead of print.PMID: 42551700 Free article.