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SCN 2020-2022 Round 2 Funding Results: Accelerating Clinical Translation Program

Principal InvestigatorCo-Investigators and CollaboratorsProject TitleSCN Funds Allocated
Lucie Germain, Université Laval (ULaval)Manuel Caruso (ULaval), Bartha Knoppers (McGill University), Elena Pope (The Hospital for Sick Children)Towards an epidermolysis bullosa clinical trial with tissue- engineered skin after ex vivo gene therapy correction$400,000
Guy Sauvageau, Université de Montréal (UMontréal), Hôpital Maisonneuve- Rosemont (HMR)Vincent-Philippe Lavallée (UMontréal), Peter Zandstra (University of British Columbia), Silvy Lachance (HMR)Bone marrow stem cell expansion with UM171: a better solution for patients and donors$400,000
James Shapiro, University of Alberta (UAlberta)Gregory Korbutt (UAlberta), Patrick MacDonald (UAlberta), Colin Anderson (UAlberta), Jean Buteau (UAlberta), Andrew Pepper (UAlberta), Timothy Kieffer (University of British Columbia)Autologous Patient- derived Islets from Induced Pluripotent Stem Cells (iPSC): The Next Generation Diabetes Therapy$400,000
Glen Tibbits, Simon Fraser University, BC Children’s Hospital Research InstituteFilip Van Petegem (University of British Columbia), Shubhayan Sanatani (University of British Columbia), Francis Lynn (University of British Columbia), SR Wayne Chen, (University of Calgary), Mu Chiao (University of British Columbia), Zachary Laksman (University of British Columbia), Patrice Eydoux (BC Children’s Hospital Research Institute), Leif Hove-Madsen (Institut d’investigacions Biomèdiques de Barcelona)Developing a hiPSC-CM based model for personalized treatment of catecholaminergic polymorphic ventricular tachycardia (CPVT)$399,950
Ann Yeh, The Hospital for Sick Children (SickKids), University of TorontoDonald Mabbott (SickKids), Douglas Munoz (Queen’s University), Freda Miller (SickKids), David Kaplan (SickKids), Cindi Morshead, (University Health Network), Jing Wang (Ottawa Hospital Research Institute), Paul Frankland (SickKids), Wolfram Tetzlaff (University of British Columbia), Jiwon Oh (St. Michael’s Hospital), Giulia Longoni (SickKids)Pharmacological recruitment of endogenous neural precursors to promote white matter repair in MS$399,997
J.C. Zúñiga-Pflücker, Sunnybrook Research InstituteDonna Wall (The Hospital for Sick Children), Jonas Mattsson (Princess Margaret Cancer Centre)Production of progenitor T cells for immune-reconstitution and targeted immunotherapies (ProTImm)$400,000

SCN 2020-2022 Round 2 Funding Results: Fueling Biotechnology Partnerships Program

Principal InvestigatorCo-Investigators and CollaboratorsProject TitleSCN Funds Allocated
Bernard Thébaud, Ottawa Hospital Research Institute (OHRI), University of Ottawa, Children’s Hospital of Eastern Ontario (CHEO)Sarah Wootton (University of Guelph), Dean Fergusson (OHRI), Rénald Gilbert (National Research Council Canada), Parminder Chahal (National Research Council Canada), John Bell (OHRI), Amine Kamen (McGill University), Larry Nogee (John Hopkins University School of Medicine), Jeffrey Whitsett (University of Cincinnati), Alice Tarantal (UC Davis School of Medicine), Michael Jamieson (OHRI), Hartmut Grasemann (University of Toronto), Nicolaus Schwerk (Hannover Medical School), Matthias Griese (Ludwig-Maximilian Universität), Kednapa Thavorn (OHRI)AAVenger: Adeno- Associated Virus Engineered Gene Epithelial progenitor cell Regeneration$364,000
Peter Zandstra, University of British Columbia (UBC)
Robert Holt (UBC), David Knapp (Université de Montréal), J.C. Zúñiga-Pflücker (Sunnybrook
Research Institute), Christopher Sturgeon (Washington University School of Medicine)
Enabling a platform for customized pluripotent stem cell derived T-cell therapies$350,000

SCN 2020-2022 Round 2 Funding Results: Innovative Research Program for Early Career Investigators

Principal InvestigatorCo-Investigators and CollaboratorsProject TitleSCN Funds Allocated
Natasha Chang, McGill University
Imed Gallouzi (McGill University), Jerry Pelletier (McGill University), Gerald Pfeffer (University of Calgary)Targeting muscle stem cells to enhance endogenous repair in Duchenne muscular dystrophy$150,000
Jessica Esseltine, Memorial University of NewfoundlandKathleen Hodgkinson (Memorial University of Newfoundland), Terry-Lynn Young (Memorial University of Newfoundland), Darren O’Rielly (Eastern Health Molecular Genetics Lab), Sean Connors (Memorial University of Newfoundland), Bruno Stuyvers (Memorial University of Newfoundland)A personalized, translational approach to understanding inherited Arrhythmogenic Right Ventricular Cardiomyopathy in Newfoundland$150,000
Mireille Khacho, University of Ottawa (UOttawa)Jodi Warman (UOttawa), Mary-Ellen Harper (UOttawa), Julie St. Pierre (UOttawa), William Stanford (UOttawa), Michael Rudnicki (UOttawa), Valentina Perissi (Boston University)Mitochondrial dynamics as a therapeutic target for muscle stem cells in muscle wasting diseases$150,000
Yun Li, The Hospital for Sick Children (SickKids)Julien Muffat (SickKids), Michael Wilson (SickKids), Lu-Yang Wang (SickKids)Engineering an organoid model of the hippocampal neurogenic niche for basic and translational research$150,000
Stephanie Protze, McEwen Stem Cell Institute, University Health NetworkZachary Laksman (University of British Columbia), Michael Laflamme (University Health Network), Gary Bader (University of Toronto), Igor Efimov (George Washington University)Developing stem cell- based biological pacemakers for patients with sick sinus syndrome$150,000
Jo Anne Stratton, McGill University
Tom Durcan (McGill University), Luke Healy (McGill University)Human iPSC ependymal cells: An innovative model to study human brain in health and disease$150,000
Amy Wong, The Hospital for Sick Children (Sickkids)Sidhartha Goyal (University of Toronto), Brent Stead (Specific Biologics Inc.)Elucidating the role of CFTR in human fetal lung lineage development$150,000

SCN 2020-2022 Round 2 Funding Results: Translation & Society Team Awards

Principal InvestigatorCo-Investigators and CollaboratorsProject TitleSCN Funds Allocated
Bernard Thébaud, Ottawa Hospital Research Institute (OHRI), University of Ottawa, Children’s Hospital of Eastern Ontario (CHEO)Manoj Lalu (OHRI), Kelly Cobey (OHRI), Jacques Galipeau (University of Wisconsin-Madison), Donald G. Phinney (The Scripps Research Institute), Douglas Sipp (Keio University), Michael Matthay (University of California), Tania Bubela (Simon Fraser University), Michael Rosu-Myles (Health Canada), Dean Fergusson (OHRI), David Moher (OHRI), Jeremy Grimshaw (OHRI)Clearing-up the stem- cell-mess: Delphi- based definition and reporting guidelines to improve transparency in MSC research$175,000

SCN COVID-19 Rapid Response Research Initiative Funding Results

Principal InvestigatorCo-Investigators and CollaboratorsProject TitleSCN Funds Allocated
Duncan Stewart, Ottawa Hospital Research Institute (OHRI) Dean Fergusson (OHRI), Shane English (OHRI), Manoj M. Lalu (OHRI), Bernard Thébaud (OHRI), David Courtman (OHRI)Cellular Immuno-Therapy for COVID-19 induced Acute Respiratory Distress Syndrome: the CIRCA-19 Trial$300,000
William Stanford, Ottawa Hospital Research Institute (OHRI)
Amy Wong (The Hospital for Sick Children), Molly Shoichet (University of Toronto), Stephen Juvet (University of Toronto), Samira Mubareka (Sunnybrook Research Institute), Scott Gray-Owen (University of Toronto), Mitchell Sabloff (OHRI)Identifying and targeting pulmonary and immune mechanisms in COVID-19 using human stem cell derived lineages$195,870
Julien Muffat, The Hospital for Sick Children (SickKids)
Yun Li (SickKids), Samira Mubareka (Sunnybrook Research Institute), Scott Gray-Owen (University of Toronto), Jason Moffat (University of Toronto), Louis Flamand (CHU de Quebéc-Université Laval)Investigating the role of inflammatory responses in neurological effects of COVID-19, using patient-derived stem cell models$180,000

SCN 2019-2022 Round 1 Funding Results: Accelerating Clinical Translation Program

Principal Investigator Co-Investigators and Collaborators Project TitleSCN Funds Allocated
Zachary Laksman, University of British Columbia (UBC)Gordon Keller (University Health Network) Glen Tibbits (UBC), Liam Brunham (UBC), David Vocadlo (Simon Fraser University), Francis Lynn (UBC), Lior Gepstein (Technion – Israel Institute of Technology), Patrick Boyle (University of Washington), Shubhayan Sanatani (BC Children’s Hospital Research Institute) Pipeline Towards Stem Cell Driven Personalized Medicine for Atrial Fibrillation$586,000
Michael Laflamme, McEwen Stem Cell Institute, University Health Network (UHN)Nilesh Ghugre (Sunnybrook Research Institute), Graham Wright (Sunnybrook Research Institute), Gordon Keller (UHN), Ren-Ke Li (UHN), Terrence Yau (UHN), Kumaraswamy Nanthakumar (UHN), Lior Gepstein (Technion – Israel Institute of Technology), Matthew Kay (George Washington University)Heart Regeneration with Mature Ventricular Cardiomyocytes from Human Pluripotent Stem Cells$599,685
M. Cristina Nostro, McEwen Stem Cell Institute, University Health Network (UHN), University of TorontoGreg Korbutt (University of Alberta), Andrew Pepper (University of Alberta), Esme Dijke (University of Alberta), James Shapiro (University of Alberta), Joanna Preston (TEC Edmonton), Atul Humar (UHN)Co-localized hiPSC-derived Beta Cells and Immunosuppression-loaded Micelles as a Novel Approach for T1D Treatment$600,000
Bruce Verchere, University of British Columbia (UBC)Francis Lynn (UBC), Megan Levings (UBC), Tim Kieffer (UBC), Dina Panagiotopoulos (UBC), Brad Hoffman (UBC), Greg Korbutt (University of Alberta)Genetic Manipulation of hES-derived Insulin-producing Cells to Improve Graft Outcomes$600,000

SCN 2019-2022 Round 1 Funding Results: Fueling Biotechnology Partnerships Program

Principal InvestigatorCo-Investigators and Collaborators Project TitleSCN Funds Allocated
Gilbert Bernier, Hôpital Maisonneuve-Rosemont (HMR), Université de Montréal (UMontréal)May Griffith (HMR), Jean-François Bouchard (UMontréal), Stéphane Faubert (St-Hyacinthe Veterinary School), Cynthia Qian (HMR), Flavio Rezende (HMR)Photoreceptor Transplantation for the Treatment of Retinal Degenerative Diseases$500,000
Tim Kieffer, University of British Columbia (UBC)Corinne Hoesli (McGill University), James Piret (UBC), Megan Levings (UBC), Steven Paraskevas (The Research Institute of McGill University Health Centre), Richard Leask (McGill University), Patrick MacDonald (University of Alberta)A Bioprinted Insulin-Producing Device for Diabetes$500,000
Massimiliano Paganelli (CHU-Sainte-Justine, Université de Montréal (UMontréal)Christopher Rose (UMontréal), Michel Lallier (CHU-Sainte-Justine), Constantine Karvellas (University of Alberta), Siofradh McMahon (CCRM)iPSC-derived Encapsulated Liver Tissue to Treat Acute Liver Failure: Pivotal Confirmation in Large Animals $500,000

SCN 2019-2022 Round 1 Funding Results: Advancing Clinical Trials Program

Principal InvestigatorCo-Investigators and Collaborators Project TitleSCN Funds Allocated
Sandra Cohen, Hôpital Maisonneuve-Rosemont (HMR), Université de Montréal (UMontréal)Jean-Sébastien Delisle (HMR), Gizelle Popradi (McGill University Hospital Center), Frédéric Barabé (Centre de recherche CHU de Québec-Université Laval), Nadia Bambace (HMR), Léa Bernard (HMR), Guy Sauvageau (UMontréal), Josée Hébert (UMontréal), Filippo Milano (Fred Hutchinson Cancer Research Center), Peter Zandstra (University of British Columbia), Sébastien Lemieux (UMontréal), Gabriel Tremblay (Purple Squirrel Economics), Lambert Busque (HMR), Denis-Claude Roy (HMR) UM171-Expanded Cord Blood Grafts Offer Potential Cure for Very High-Risk Leukemia Patients$1,000,000
Lucie Germain, Université Laval (ULaval) François A. Auger (ULaval), Bartha M. Knoppers (McGill University), Richard Bazin (ULaval), Isabelle Brunette (UMontréal), Allan Slomovic (Toronto Western Hospital), Mohib Morcos (McGill University), Michel Ouellet (Patient representative), Charles Giguère (Centre de recherche de l'Institut universitaire en santé mentale de Montréal)Cultured Epithelial Corneal Autografts for the Treatment of Canadians with Limbal Stem Cell Deficiency $500,000
Véronique Moulin, Université Laval (ULaval)François A. Auger (ULaval), Lucie Germain (ULaval), Bartha M. Knoppers (McGill University), Isabelle Perreault (CHU-Sainte-Justine), Sarvesh Logsetty (Winnipeg Burn Unit), Ariane Bussière (Québec Burn Unit), Patricia Bortoluzzi (CHU-Sainte-Justine), Vince Gabriel (Calgary Firefighter Burn Treatment Centre), Duncan Nickerson (Calgary Firefighter Burn Treatment Centre), Sally Hynes (BC Children’s Hospital Research Institute), Edward Tredget (Walter C. Mackenzie Health Sciences Centre), Josh Wong (Walter C. Mackenzie Health Sciences Centre), Peter Kwan (Walter C. Mackenzie Health Sciences Centre), Joel Fish (The Hospital for Sick Children), Claudia Malik (Children’s Hospital of Eastern Ontario), Marc Jeschke (Sunnybrook Research Institute), Sue-Ling Chang (Patient representative)Self-Assembly Skin Substitutes (SASS) for the Treatment of Acute Wounds of Canadian Burn Patients$470,645
Bernard Thébaud, Ottawa Hospital Research Institute (OHRI), University of Ottawa (UOttawa), Children’s Hospital of Eastern Ontario (CHEO)Dean Fergusson (OHRI), Justin Presseau (UOttawa), Kednapa Thavorn (UOttawa), Brigitte Lemyre (CHEO), Mario Ruediger (Technische Universität Dresden), Nadya Ben Fadel (CHEO), Robert Jankov (CHEO), Jana Feberova (CHEO), David Courtman (OHRI)HULC-I: Helping Underdeveloped Lungs with Mesenchymal Stromal Cells – A phase I Trial$638,150

SCN 2019-2022 Round 1 Funding Results: Translation and Society Program

Principal InvestigatorCo-Investigators and CollaboratorsProject TitleSCN Funds Allocated
Bartha M. Knoppers, McGill UniversityChristine Bear (The Hospital for Sick Children), Felix Ratjen (The Hospital for Sick Children), Amy Wong (The Hospital for Sick Children), Paul Eckford (The Hospital for Sick Children), Elizabeth Stephenson (The Hospital for Sick Children), Michael Szego (University of Toronto), Julie Fradette (Université Laval), Mark Rothstein (University of Louisville School of Medicine)Ethical and Legal Framework for Direct-to-Participant (DTP) Recruitment$75,000

SCN 2019-2022 Round 1 Funding Results: Disruptive Research Award

Principal InvestigatorCo-Investigators and CollaboratorsProject TitleSCN Funds Allocated
Florian Bentzinger, Université de Sherbrooke (USherbrooke)Eric Marsault (USherbrooke), Penney Gilbert (University of Toronto), Mannix Auger-Messier (USherbrooke), Ubaka Ogbogu (University of Alberta), Jerome Feige (Nestlé Research), Nicolas Dumont (CHU-Sainte-Justine), Alison McGuigan (University of Toronto)Targeting Endogenous Repair: A Novel Mutation Independent Pharmacological Approach for Treatment of Muscular Dystrophy $330,000

SCN 2019-2022 Round 1 Funding Results Summary

Applications Received Applications Recommended for FundingPercentage of Successful ApplicationsTotal Investment
371335%$6.9 million

* Project titles posted as per the language of submission

2016-2022 Funding Results