Discover the science conducted by stem cell and RM researchers

MARCH

Optimizing Electrical Field Stimulation Parameters Reveals the Maximum Contractile Function of Human Skeletal Muscle Microtissues. Tiper Y, Xie Z, Hofemeier AD, Lad H, Luber M, Krawetz R, Betz T, Zimmermann WH, Morton AB, Segal SS, Gilbert PM. Am J Physiol Cell Physiol. 2025 Feb 28. doi: 10.1152/ajpcell.00308.2024. Online ahead of print.PMID: 40019026

Intrinsic Muscle Stem Cell Dysfunction Contributes to Impaired Regeneration in the mdx Mouse. Esper ME, Brun CE, Lin AYT, Feige P, Catenacci MJ, Sincennes MC, Ritso M, Rudnicki MA. J Cachexia Sarcopenia Muscle. 2025 Feb;16(1):e13682. doi: 10.1002/jcsm.13682. PMID: 39723578 Free PMC article.

Delphi-driven consensus definition for mesenchymal stromal cells and clinical reporting guidelines for mesenchymal stromal cell-based therapeutics. Renesme L, Cobey KD, Lalu MM, Bubela T, Chinnadurai R, De Vos J, Dunbar R, Fergusson D, Freund D, Galipeau J, Horwitz E, Lê M, Matthay M, Moher D, Nolta J, Parker G, Phinney DG, Rao M, Rasko JEJ, Rocco PRM, Rossi F, Myles MR, Viswanathan S, Thébaud B. Cytotherapy. 2025 Feb;27(2):146-168. doi: 10.1016/j.jcyt.2024.10.008. Epub 2024 Oct 29. PMID: 39580717

3D Bioprinted Coaxial Testis Model Using Human Induced Pluripotent Stem Cells:A Step Toward Bicompartmental Cytoarchitecture and Functionalization. Robinson MA, Kung SH, Youssef KY, Scheck KM, Bell RH, Sar F, Haegert AM, Asmae MM, Cheng C, Yeack SV, Mathur BT, Jiang F, Collins CC, Hach F, Willerth SM, Flannigan RK. Adv Healthc Mater. 2025 Feb 16:e2402606. doi: 10.1002/adhm.202402606. Online ahead of print. PMID: 39955738

Timing neural development and regeneration. Blackshaw S, Cayouette M. Curr Opin Neurobiol. 2025 Feb 25;91:102976. doi: 10.1016/j.conb.2025.102976. Online ahead of print. PMID: 40010202 Review.

Assessment of immune modulation strategies to enhance survival and integration of human neural progenitor cells in rodent models of spinal cord injury. Lou Z, Post A, Nagoshi N, Hong J, Hejrati N, Chio JCT, Khazaei M, Fehlings MG. Stem Cells Transl Med. 2025 Feb 11;14(2):szae090. doi: 10.1093/stcltm/szae090. PMID: 39931999 Free PMC article. Review.

Effect of Fibroblast Growth Factor-2 on Melanocyte Proliferation in Tissue-Engineered Skin Substitutes. Ferland K, Magne B, De Koninck H, Barbier MA, Larouche D, Germain L. Int J Mol Sci. 2025 Feb 17;26(4):1704. doi: 10.3390/ijms26041704. PMID: 40004167 Free PMC article.

3D Bioprinted Coaxial Testis Model Using Human Induced Pluripotent Stem Cells:A Step Toward Bicompartmental Cytoarchitecture and Functionalization. Robinson MA, Kung SH, Youssef KY, Scheck KM, Bell RH, Sar F, Haegert AM, Asmae MM, Cheng C, Yeack SV, Mathur BT, Jiang F, Collins CC, Hach F, Willerth SM, Flannigan RK. Adv Healthc Mater. 2025 Feb 16:e2402606. doi: 10.1002/adhm.202402606. Online ahead of print. PMID: 39955738

Recent advances in 3D bioprinted neural models: A systematic review on the applications to drug discovery. Orr A, Kalantarnia F, Nazir S, Bolandi B, Alderson D, O’Grady K, Hoorfar M, Julian LM, Willerth SM. Adv Drug Deliv Rev. 2025 Mar;218:115524. doi: 10.1016/j.addr.2025.115524. Epub 2025 Feb 1. PMID: 39900293 Review.

Bioprinting-By-Design of Hydrogel-Based Biomaterials for In Situ Skin Tissue Engineering. Douglas A, Chen Y, Elloso M, Levschuk A, Jeschke MG. Gels. 2025 Feb 3;11(2):110. doi: 10.3390/gels11020110. PMID: 39996653 Free PMC article. Review.

Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke. Bernier LP, Hefendehl JK, Scott RW, Tung LW, Lewis CA, Soliman H, Simm S, Dissing-Olesen L, Hofmann J, Guo D, DeMeglio M, Rossi FM, Underhill TM, MacVicar BA. Nat Neurosci. 2025 Feb 17. doi: 10.1038/s41593-025-01872-y. Online ahead of print. PMID: 39962273

Identification of a Therapeutic Window for Neurovascular Unit Repair after Experimental Spinal Cord Injury. Hubertus V, Meyer L, Waldmann L, Roolfs L, Taheri N, Kersting K, von Bronewski E, Nieminen-Kelhä M, Kremenetskaia I, Uhl C, Fiedler KC, Ode JE, Rex A, Prüß H, Rakhymzhan A, Hauser AE, Niesner R, Heppner FL, Fehlings MG, Vajkoczy P. J Neurotrauma. 2025 Feb;42(3-4):212-228. doi: 10.1089/neu.2024.0233. Epub 2024 Nov 26. PMID: 39585767

FEBRUARY

PTPN1/2 inhibition promotes muscle stem cell differentiation in Duchenne muscular dystrophy. Liu Y, Li S, Robertson R, Granet JA, Aubry I, Filippelli RL, Tremblay ML, Chang NC. Life Sci Alliance. 2024 Oct 30;8(1):e202402831. doi: 10.26508/lsa.202402831. Print 2025 Jan. PMID: 39477543 Free PMC article.

Atrial Fibrillation Related Titin Truncation Is Associated With Atrial Myopathy in Patient-Derived Induced Pluripotent Stem Cell Disease Models. Huang K, Ashraf M, Rohani L, Luo Y, Sacayanan A, Huang H, Haegert A, Volik S, Sar F, LeBihan S, Liew J, Backx PH, Roberts JD, Tibbits GF, Churko JM, Sanatani S, Collins C, Brunham LR, Laksman ZW. Circ Genom Precis Med. 2025 Jan 24:e004412. doi: 10.1161/CIRCGEN.123.004412. Online ahead of print. PMID: 39851047

Single cell approaches define neural stem cell niches and identify microglial ligands that can enhance precursor-mediated oligodendrogenesis. Willis A, Jeong D, Liu Y, Lithopoulos MA, Yuzwa SA, Frankland PW, Kaplan DR, Miller FD. Cell Rep. 2025 Jan 28;44(1):115194. doi: 10.1016/j.celrep.2024.115194. Epub 2025 Jan 15. PMID: 39823226

Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead. Grattoni A, Korbutt G, Tomei AA, García AJ, Pepper AR, Stabler C, Brehm M, Papas K, Citro A, Shirwan H, Millman JR, Melero-Martin J, Graham M, Sefton M, Ma M, Kenyon N, Veiseh O, Desai TA, Nostro MC, Marinac M, Sykes M, Russ HA, Odorico J, Tang Q, Ricordi C, Latres E, Mamrak NE, Giraldo J, Poznansky MC, de Vos P. Nat Rev Endocrinol. 2025 Jan;21(1):14-30. doi: 10.1038/s41574-024-01029-0. Epub 2024 Sep 3. PMID: 39227741 Review.

ISCT MSC committee statement on the US FDA approval of allogenic bone-marrow mesenchymal stromal cells. Blanc KL, Dazzi F, English K, Farge D, Galipeau J, Horwitz EM, Kadri N, Krampera M, Lalu MM, Nolta J, Patel NM, Shi Y, Weiss DJ, Viswanathan S.Cytotherapy. 2025 Jan 17:S1465-3249(25)00030-1. doi: 10.1016/j.jcyt.2025.01.005. Online ahead of print.PMID: 39864015

Novel Immune Response Evasion Strategy to Redose Adeno-associated Viral Vectors and Prolong Survival in Surfactant Protein-B Deficient Mice. Kang MH, Thomas SP, Westley C, Blouin T, Xu L, Chan YK, Lisk E, Allen S, Vadivel A, Nangle K, Ramamurthy J, Pei Y, Lewis L, Chiang JJ, Romeo MJ, Vaena S, O’Quinn EC, Schrecker HD, Langdon CG, Nietert PJ, Church GM, Whitsett JA, Wootton SK, Thébaud B.Am J Respir Cell Mol Biol. 2025 Jan 13. doi: 10.1165/rcmb.2024-0247OC. Online ahead of print.PMID: 39805087

Advances in physiological and clinical relevance of hiPSC-derived brain models for precision medicine pipelines. Imani Farahani N, Lin L, Nazir S, Naderi A, Rokos L, McIntosh AR, Julian LM.Front Cell Neurosci. 2025 Jan 6;18:1478572. doi: 10.3389/fncel.2024.1478572. eCollection 2024.PMID: 39835290 Free PMC article. Review.

A Pilot Study of UM171-Expanded Cord Blood Grafts for Tandem Auto/Allogeneic Hematopoietic Cell Transplant in High and Ultra-High-Risk Myeloma Patients. Roy J, Cohen S, Sauvageau G, Ahmad I, Fournier V, Terra R, Caudrelier P, Thiant S, Thauvette G, Bambace N, Delisle JS, Lachance S, Kiss T, Bernard L, Roy DC, Veilleux O, LeBlanc R.Transplant Cell Ther. 2025 Jan;31(1):34.e1-34.e14. doi: 10.1016/j.jtct.2024.10.008. Epub 2024 Oct 16.PMID: 39419177

Approach to autologous stem cell transplantation in a patient with severe cold agglutinin disease, a case report. Castonguay M, Bernard L, Corriveau M, Castonguay A, Quenneville G, Cohen S, Lachance S, Ahmad I, Cournoyer I, Kiss T, Fleury I, Mollica L, Roy DC, Roy J, Sauvageau G, Veilleux O, Giroux M, Delisle JS, Boileau M.Transfusion. 2025 Jan 28. doi: 10.1111/trf.18147. Online ahead of print.PMID: 39876551