Discover the science conducted by stem cell and RM researchers

NOVEMBER

Embryonic macrophages support endocrine commitment during human pancreatic differentiation. Migliorini A, Ge S, Atkins MH, Oakie A, Sambathkumar R, Kent G, Huang H, Sing A, Chua C, Gehring AJ, Keller GM, Notta F, Nostro MC. Cell Stem Cell. 2024 Oct 10:S1934-5909(24)00325-4. doi: 10.1016/j.stem.2024.09.011. Online ahead of print. PMID: 39406230

Synthesizing regulatory guidance for demonstrating preclinical efficacy and translating promising cell therapies to early phase clinical trials: a scoping review. Jeffers MS, Xi CE, Bapuji R, Wotherspoon H, Kimmelman J, Bedford P, McIsaac DI, Lalu MM, Fergusson DA. BMC Med. 2024 Oct 23;22(1):487. doi: 10.1186/s12916-024-03690-8. PMID: 39443960 Free PMC article. Review.

Sex-biased human thymic architecture guides T cell development through spatially defined niches. Stankiewicz LN, Salim K, Flaschner EA, Wang YX, Edgar JM, Durland LJ, Lin BZB, Bingham GC, Major MC, Jones RD, Blau HM, Rideout EJ, Levings MK, Zandstra PW, Rossi FMV. Dev Cell. 2024 Oct 3:S1534-5807(24)00539-2. doi: 10.1016/j.devcel.2024.09.011. Online ahead of print. PMID: 39383865

A Pilot Study of UM171-Expanded Cord Blood Grafts for Tandem Auto/Allogeneic Hematopoietic Cell Transplant in High and Ultra-High-Risk Myeloma Patients. Roy J, Cohen S, Sauvageau G, Ahmad I, Fournier V, Terra R, Caudrelier P, Thiant S, Thauvette G, Bambace N, Delisle JS, Lachance S, Kiss T, Bernard L, Roy DC, Veilleux O, LeBlanc R. Transplant Cell Ther. 2024 Oct 16:S2666-6367(24)00724-3. doi: 10.1016/j.jtct.2024.10.008. Online ahead of print. PMID: 39419177

The emerging role of generative artificial intelligence in transplant medicine. Deeb M, Gangadhar A, Rabindranath M, Rao K, Brudno M, Sidhu A, Wang B, Bhat M. Am J Transplant. 2024 Oct;24(10):1724-1730. doi: 10.1016/j.ajt.2024.06.009. Epub 2024 Jun 18. PMID: 38901561 Review.

Lab-on-a-chip models of cardiac inflammation. Popovic AM, Lei MHC, Shakeri A, Khosravi R, Radisic M. Biomicrofluidics. 2024 Oct 29;18(5):051507. doi: 10.1063/5.0231735. eCollection 2024 Sep. PMID: 39483204 Review.

PTPN1/2 inhibition promotes muscle stem cell differentiation in Duchenne muscular dystrophy. Liu Y, Li S, Robertson R, Granet JA, Aubry I, Filippelli RL, Tremblay ML, Chang NC. Life Sci Alliance. 2024 Oct 30;8(1):e202402831. doi: 10.26508/lsa.202402831. Print 2025 Jan. PMID: 39477543 Free PMC article.

β-Adrenergic blockade attenuates adverse adipose tissue responses after burn. Bieerkehazhi S, Abdullahi A, Khalaf F, Barayan D, de Brito Monteiro L, Samadi O, Rix G, Jeschke MG. J Mol Med (Berl). 2024 Oct;102(10):1245-1254. doi: 10.1007/s00109-024-02478-w. Epub 2024 Aug 15. PMID: 39145814

Choroidal melanocyte secretome from cultured cells and tissue-engineered choroid models exposed to acute or chronic oxidative stress. Karami S, Landreville S, Proulx S. Exp Eye Res. 2024 Oct 13;249:110125. doi: 10.1016/j.exer.2024.110125. Online ahead of print. PMID: 39406316

Developing a Soft Micropatterned Substrate to Enhance Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Maaref Y, Jannati S, Jayousi F, Lange P, Akbari M, Chiao M, Tibbits GF. Acta Biomater. 2024 Oct 26:S1742-7061(24)00621-4. doi: 10.1016/j.actbio.2024.10.029. Online ahead of print. PMID: 39490605

Isolation of small extracellular vesicles from regenerating muscle tissue using tangential flow filtration and size exclusion chromatography. Gurriaran-Rodriguez U, De Repentigny Y, Kothary R, Rudnicki MA. Skelet Muscle. 2024 Oct 11;14(1):22. doi: 10.1186/s13395-024-00355-1. PMID: 39394606 Free PMC article.

Establishment of a new human iPSC cell line (UOMi012-A) from a patient with congenital heart defect who has undergone Fontan procedure. Sareen N, Srivastava A, Mittal I, Shah AH, Dhingra S. Stem Cell Res. 2024 Oct;80:103509. doi: 10.1016/j.scr.2024.103509. Epub 2024 Jul 28. PMID: 39089181

Astrocytes originated from neural stem cells drive the regenerative remodeling of pathologic CSPGs in spinal cord injury. Hosseini SM, Nemati S, Karimi-Abdolrezaee S. Stem Cell Reports. 2024 Oct 8;19(10):1451-1473. doi: 10.1016/j.stemcr.2024.08.007. Epub 2024 Sep 19. PMID: 39303705

OCTOBER

Advanced Regenerative Medicines for Rare Diseases: A Review of Industry Sponsors Investment Motivations.
Ogbogu U, Nel A. Ther Innov Regul Sci. 2024 Sep 10. doi: 10.1007/s43441-024-00690-x. Online ahead of print. PMID: 39256324 Review.

Influence of mesenchymal and biophysical components on distal lung organoid differentiation.
Goltsis O, Bilodeau C, Wang J, Luo D, Asgari M, Bozec L, Pettersson A, Leibel SL, Post M. Stem Cell Res Ther. 2024 Sep 2;15(1):273. doi: 10.1186/s13287-024-03890-2. PMID: 39218985 Free PMC article.

Endothelial extracellular vesicles enhance vascular self-assembly in engineered human cardiac tissues.
Wagner KT, Lu RXZ, Landau S, Shawky SA, Zhao Y, Bodenstein DF, Jiménez Vargas LF, Jiang R, Okhovatian S, Wang Y, Liu C, Vosoughi D, Gustafson D, Fish JE, Cummins CL, Radisic M. Biofabrication. 2024 Sep 18;16(4):045037. doi: 10.1088/1758-5090/ad76d9. PMID: 39226913 Free PMC article.

Protocol for the efficient and inducible generation of CRISPR-Cas9-edited human cortical neurons from the iCas9-iNgn2 hPSCs.
Dhaliwal NK, Weng OY, Li Y. STAR Protoc. 2024 Sep 28;5(4):103352. doi: 10.1016/j.xpro.2024.103352. Online ahead of print. PMID: 39342621

Advances in human In vitro spermatogenesis: A review.
Nguyen AV, Julian S, Weng N, Flannigan R. Mol Aspects Med. 2024 Sep 23;100:101320. doi: 10.1016/j.mam.2024.101320. Online ahead of print. PMID: 39317014 Review.

Redesigned chondroitinase ABC degrades inhibitory chondroitin sulfate proteoglycans in vitro and in vivo in the stroke-injured rat brain.
Letko Khait N, Zuccaro S, Abdo D, Cui H, Siu R, Ho E, Morshead CM, Shoichet MS. Biomaterials. 2024 Sep 7;314:122818. doi: 10.1016/j.biomaterials.2024.122818. Online ahead of print. PMID: 39260032

Design of an innovative method for measuring the contractile behaviour of engineered tissues.
Savard É, Magne B, Simard-Bisson C, Martel C, Larouche D, Gauvin R, Moulin VJ, Germain L. Tissue Eng Part C Methods. 2024 Sep 23. doi: 10.1089/ten.TEC.2024.0228. Online ahead of print. PMID: 39311467

Therapeutic characteristics of alveolar-like macrophages in mouse models of hyperoxia and LPS-induced lung inflammation.
Litman K, Bouch S, Litvack ML, Post M. Am J Physiol Lung Cell Mol Physiol. 2024 Sep 1;327(3):L269-L281. doi: 10.1152/ajplung.00270.2023. Epub 2024 Jun 18. PMID: 38887793 Free PMC article.

Antenatal Administration of Extracellular Vesicles Derived From Amniotic Fluid Stem Cells Improves Lung Function in Neonatal Rats With Congenital Diaphragmatic Hernia.
Figueira RL, Khoshgoo N, Doktor F, Khalaj K, Islam T, Moheimani N, Blundell M, Antounians L, Post M, Zani A. J Pediatr Surg. 2024 Sep;59(9):1771-1777. doi: 10.1016/j.jpedsurg.2024.02.029. Epub 2024 Feb 28.PMID: 38519389

The Interactions of T Cells with Myeloid-Derived Suppressor Cells in Peripheral Blood Stem Cell Grafts.
Guan Q, Gilpin SG, Doerksen J, Bath L, Lam T, Li Y, Lambert P, Wall DA. Cells. 2024 Sep 14;13(18):1545. doi: 10.3390/cells13181545. PMID: 39329729 Free PMC article.

Genetic engineering of megakaryocytes from blood progenitor cells using mRNA lipid nanoparticles.
Leung J, Primbetova A, Strong C, Hay BN, Hsu HH, Hagner A, Foster LJ, Devine D, Cullis PR, Zandstra PW, Kastrup CJ. J Thromb Haemost. 2024 Sep 26:S1538-7836(24)00553-1. doi: 10.1016/j.jtha.2024.09.008. Online ahead of print. PMID: 39341369