Discover the science conducted by stem cell and RM researchers

AUGUST

SOX9 reprograms endothelial cells by altering the chromatin landscape.
Fuglerud BM, Drissler S, Lotto J, Stephan TL, Thakur A, Cullum R, Hoodless PA.
Nucleic Acids Res. 2022 Jul 29:gkac652. doi: 10.1093/nar/gkac652. Online ahead of print.
PMID: 35904801

Comparison of freshly cultured versus cryopreserved mesenchymal stem cells in animal models of inflammation: A pre-clinical systematic review. Dave C, Mei SHJ, McRae A, Hum C, Sullivan KJ, Champagne J, Ramsay T, McIntyre L.
Elife. 2022 Jul 15;11:e75053. doi: 10.7554/eLife.75053.

GLI3 regulates muscle stem cell entry into G_Alert and self-renewal.
Brun CE, Sincennes MC, Lin AYT, Hall D, Jarassier W, Feige P, Le Grand F, Rudnicki MA.
Nat Commun. 2022 Jul 8;13(1):3961. doi: 10.1038/s41467-022-31695-5.
PMID: 35803939 Free PMC article.

Renal organoid modeling of tuberous sclerosis complex reveals lesion features arise from diverse developmental processes.
Pietrobon A, Yockell-Lelièvre J, Flood TA, Stanford WL.
Cell Rep. 2022 Jul 5;40(1):111048. doi: 10.1016/j.celrep.2022.111048.
PMID: 35793620

A three-dimensional human adipocyte model of fatty acid-induced obesity.
Pieters V, Rjaibi ST, Singh K, Li NT, Khan ST, Nunes SS, Dal Cin A, Gilbert P, McGuigan AP.
Biofabrication. 2022 Jul 27. doi: 10.1088/1758-5090/ac84b1. Online ahead of print.
PMID: 35896099

Unified gene expression signature of novel NPM1 exon 5 mutations in acute myeloid leukemia.
Lisi V, Blanchard È, Vladovsky M, Audemard E, Ferghaly A, Lemieux S, Hebert J, Sauvageau G, Lavallee VP.
Blood Adv. 2022 Jul 18:bloodadvances.2022007300. doi: 10.1182/bloodadvances.2022007300. Online ahead of print.
PMID: 35849707 No abstract available.

The effect of Mg²⁺ on Ca²⁺ binding to cardiac troponin C in hypertrophic cardiomyopathy associated TNNC1 variants.
Rayani K, Hantz ER, Haji-Ghassemi O, Li AY, Spuches AM, Van Petegem F, Solaro RJ, Lindert S, Tibbits GF.
FEBS J. 2022 Jul 15. doi: 10.1111/febs.16578. Online ahead of print.
PMID: 35838319

Thymus Reconstitution in Young and Aged Mice Is Facilitated by In Vitro-Generated Progenitor T Cells.
Mohtashami M, Li YR, Lee CR, Zúñiga-Pflücker JC.
Front Immunol. 2022 Jul 8;13:926773. doi: 10.3389/fimmu.2022.926773. eCollection 2022.
PMID: 35874726 Free PMC article.

Toward Hierarchical Assembly of Aligned Cell Sheets into a Conical Cardiac Ventricle Using Microfabricated Elastomers.
Mohammadi MH, Okhovatian S, Savoji H, Campbell SB, Lai BFL, Wu J, Pascual-Gil S, Bannerman D, Rafatian N, Li RK, Radisic M.
Adv Biol (Weinh). 2022 Jul 7:e2101165. doi: 10.1002/adbi.202101165. Online ahead of print.
PMID: 35798316

Directed Evolution Enables Simultaneous Controlled Release of Multiple Therapeutic Proteins from Biopolymer-Based Hydrogels.
Teal CJ, Hettiaratchi MH, Ho MT, Ortin-Martinez A, Ganesh AN, Pickering AJ, Golinski AW, Hackel BJ, Wallace VA, Shoichet MS.
Adv Mater. 2022 Jul 5:e2202612. doi: 10.1002/adma.202202612. Online ahead of print.
PMID: 35790035

Exome/Genome-Wide Testing in Newborn Screening: A Proportionate Path Forward.
Rahimzadeh V, Friedman JM, de Wert G, Knoppers BM.
Front Genet. 2022 Jul 4;13:865400. doi: 10.3389/fgene.2022.865400. eCollection 2022.
PMID: 35860465 Free PMC article.

Isolating Nuclei From Frozen Human Heart Tissue for Single-Nucleus RNA Sequencing.
Safabakhsh S, Sar F, Martelotto L, Haegert A, Singhera G, Hanson P, Parker J, Collins C, Rohani L, Laksman Z.
Curr Protoc. 2022 Jul;2(7):e480. doi: 10.1002/cpz1.480.
PMID: 35816165

Governing the futures of non-invasive prenatal testing: An exploration of social acceptability using the Delphi method.
Dupras C, Birko S, Affdal AO, Haidar H, Lemoine ME, Ravitsky V.
Soc Sci Med. 2022 Jul;304:112930. doi: 10.1016/j.socscimed.2020.112930. Epub 2020 Mar 17.
PMID: 32216981

JULY

Understanding potential barriers and enablers to a perioperative early phase cell therapy trial.
Foster M, Fergusson DA, Hunniford V, Cardenas A, Castillo G, Yaworsky J, Mazer CD, Devereaux PJ, McIsaac DI, Stewart DJ, Presseau J, Lalu MM.
Cytotherapy. 2022 Jun;24(6):629-638. doi: 10.1016/j.jcyt.2021.08.008. Epub 2022 Apr 6.
PMID: 35396169

Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics.
Babaeijandaghi F, Cheng R, Kajabadi N, Soliman H, Chang CK, Smandych J, Tung LW, Long R, Ghassemi A, Rossi FMV.
Sci Transl Med. 2022 Jun 29;14(651):eabg7504. doi: 10.1126/scitranslmed.abg7504. Epub 2022 Jun 29.
PMID: 35767650

An engineered multicellular stem cell niche for the 3D derivation of human myogenic progenitors from iPSCs.
Mashinchian O, De Franceschi F, Nassiri S, Michaud J, Migliavacca E, Aouad P, Metairon S, Pruvost S, Karaz S, Fabre P, Molina T, Stuelsatz P, Hegde N, Le Moal E, Dammone G, Dumont NA, Lutolf MP, Feige JN, Bentzinger CF.
EMBO J. 2022 Jun 15:e110655. doi: 10.15252/embj.2022110655. Online ahead of print.
PMID: 35703167

CEACAM1 is a novel culture-compatible surface marker of expanded long-term reconstituting hematopoietic stem cells.
Ansari U, Tomellini E, Chagraoui J, Lehnertz B, Mayotte N, Bordeleau ME, Roux PP, Sauvageau G.
Blood Adv. 2022 Jun 28;6(12):3626-3631. doi: 10.1182/bloodadvances.2021006835.
PMID: 35286394 No abstract available.

The Contribution of Innervation to Tissue Repair and Regeneration.
Johnston APW, Miller FD.
Cold Spring Harb Perspect Biol. 2022 Jun 6:a041233. doi: 10.1101/cshperspect.a041233. Online ahead of print.
PMID: 35667791

Quantifying Patient Investment in Novel Neurological Drug Development.
MacPherson A, Gumnit E, Ouimet C, Hutchinson N, Kieburtz K, Pearson TS, Kimmelman J.
Neurotherapeutics. 2022 Jun 28. doi: 10.1007/s13311-022-01259-y. Online ahead of print.
PMID: 35764764

Electron-Beam Irradiated Recombinant Human Collagen-Phosphorylcholine Corneal Implants Retain Pro-Regeneration Capacity.
Simpson FC, Islam MM, Buznyk O, Edin E, Groleau M, Kozak-Ljunggren M, Magrelli FM, AbuSamra DB, Argüeso P, Chodosh J, Liszka A, Fagerholm P, Griffith M.
Front Bioeng Biotechnol. 2022 Jun 13;10:883977. doi: 10.3389/fbioe.2022.883977. eCollection 2022.
PMID: 35769102 Free PMC article.

Facilitating and supporting the engagement of patients, families and caregivers in research: the “Ottawa model” for patient engagement in research.
Vanderhout S, Nicholls S, Monfaredi Z, Hampel C, Ashdown L, Bilodeau M, Rich S, Shea B, Fergusson D.
Res Involv Engagem. 2022 Jun 7;8(1):25. doi: 10.1186/s40900-022-00350-0.
PMID: 35672808 Free PMC article.

Application of machine learning in liver transplantation: a review.
Tran J, Sharma D, Gotlieb N, Xu W, Bhat M.
Hepatol Int. 2022 Jun;16(3):495-508. doi: 10.1007/s12072-021-10291-7. Epub 2022 Jan 12.
PMID: 35020154 Review.

Application of machine learning in liver transplantation: a review.
Tran J, Sharma D, Gotlieb N, Xu W, Bhat M.
Hepatol Int. 2022 Jun;16(3):495-508. doi: 10.1007/s12072-021-10291-7. Epub 2022 Jan 12.
PMID: 35020154 Review.

Recognizing patient partner contributions to health research: a mixed methods research protocol.
Fox G, Fergusson DA, Nicholls SG, Smith M, Stacey D, Lalu MM.
Res Involv Engagem. 2022 Jun 6;8(1):24. doi: 10.1186/s40900-022-00354-w.
PMID: 35668479 Free PMC article.

Molecular imaging of cellular immunotherapies in experimental and therapeutic settings.
Shalaby N, Dubois VP, Ronald J.
Cancer Immunol Immunother. 2022 Jun;71(6):1281-1294. doi: 10.1007/s00262-021-03073-5. Epub 2021 Oct 17.
PMID: 34657195 Free PMC article. Review.

Insulin Null β-cells Have a Prohormone Processing Defect That Is Not Reversed by AAV Rescue of Proinsulin Expression.
Ramzy A, Edeer N, Baker RK, O’Dwyer S, Mojibian M, Verchere CB, Kieffer TJ.
Endocrinology. 2022 Jun 1;163(6):bqac051. doi: 10.1210/endocr/bqac051. PMID: 35435956

Realization of the T Lineage Program Involves GATA-3 Induction of Bcl11b and Repression of Cdkn2b Expression.
Thompson PK, Chen ELY, de Pooter RF, Frelin C, Vogel WK, Lee CR, Venables T, Shah DK, Iscove NN, Leid M, Anderson MK, Zúñiga-Pflücker JC.
J Immunol. 2022 Jul 1;209(1):77-92. doi: 10.4049/jimmunol.2100366. Epub 2022 Jun 15.
PMID: 35705252 Free PMC article.

Reduced microglia activation following metformin administration or microglia ablation is sufficient to prevent functional deficits in a mouse model of neonatal stroke.
Bourget C, Adams KV, Morshead CM.
J Neuroinflammation. 2022 Jun 15;19(1):146. doi: 10.1186/s12974-022-02487-x.
PMID: 35705953 Free PMC article.

PTEN is required for human Treg suppression of costimulation in vitro.
Lam AJ, Haque M, Ward-Hartstonge KA, Uday P, Wardell CM, Gillies JK, Speck M, Mojibian M, Klein Geltink RI, Levings MK.
Eur J Immunol. 2022 Jun 23. doi: 10.1002/eji.202249888. Online ahead of print. PMID: 35746855