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Recent scientific publications authored by stem cell and regenerative medicine (RM) researchers

MAY

Poly(I:C) enhances mesenchymal stem cell control of myeloid cells from COVID-19 patients.
Souza-Moreira L, Tan Y, Wang Y, Wang JP, Salkhordeh M, Virgo J, Florian M, Murray ABP, Watpool I, McIntyre L, English S, Stewart DJ, Mei SHJ.
iScience. 2022 May 20;25(5):104188. doi: 10.1016/j.isci.2022.104188. Epub 2022 Apr 1.
PMID: 35402859 Free PMC article.

The international data governance landscape. 
Bernier A, Molnár-Gábor F, Knoppers BM.
J Law Biosci. 2022 Apr 4;9(1):lsac005. doi: 10.1093/jlb/lsac005. eCollection 2022 Jan-Jun.
PMID: 35382430 Free PMC article.

RARG S427L attenuates the DNA repair response to doxorubicin in induced pluripotent stem cell-derived cardiomyocytes. 
Huang H, Christidi E, Shafaattalab S, Davis MK, Tibbits GF, Brunham LR.
Stem Cell Reports. 2022 Apr 12;17(4):756-765. doi: 10.1016/j.stemcr.2022.03.002. Epub 2022 Mar 31.
PMID: 35364012 Free PMC article.

GP2-enriched pancreatic progenitors give rise to functional beta cells in vivo and eliminate the risk of teratoma formation. 
Aghazadeh Y, Sarangi F, Poon F, Nkennor B, McGaugh EC, Nunes SS, Nostro MC.
Stem Cell Reports. 2022 Apr 12;17(4):964-978. doi: 10.1016/j.stemcr.2022.03.004. Epub 2022 Mar 31.
PMID: 35364010 Free PMC article.

Building a Platform for Meaningful Patient Partnership to Accelerate “Bench-to-Bedside” Translation of Promising New Therapies. 
Fox G, Fergusson DA, Foster M, Hawrysh T, Dupont S, Walling DJ, Irwin M, Kekre N, Presseau J, Castillo G, Montroy J, Lalu MM.
Healthc Q. 2022 Apr;24(SP):74-79. doi: 10.12927/hcq.2022.26770.
PMID: 35467515

Thymic Microenvironment: Interactions Between Innate Immune Cells and Developing Thymocytes. 
Wang H, Zúñiga-Pflücker JC.
Front Immunol. 2022 Apr 8;13:885280. doi: 10.3389/fimmu.2022.885280. eCollection 2022.
PMID: 35464404 Free PMC article. Review.

Impact of home-based cognitive or academic intervention on working memory and mathematics outcomes in pediatric brain tumor survivors: the Keys to Succeed pilot randomized controlled clinical trial. 
Peterson RK, Longo C, Cunningham T, Janzen L, Guger S, Monteiro L, Rapson R, Bartels U, Bouffet E, Solomon T, Mabbott DJ.
Child Neuropsychol. 2022 Apr 18:1-25. doi: 10.1080/09297049.2022.2061933. Online ahead of print.
PMID: 35437092

Insulin null ß-cells have a prohormone processing defect that is not reversed by AAV rescue of proinsulin expression. 
Ramzy A, Edeer N, Baker RK, O’Dwyer S, Mojibian M, Verchere CB, Kieffer TJ.
Endocrinology. 2022 Apr 18:bqac051. doi: 10.1210/endocr/bqac051. Online ahead of print.
PMID: 35435956 

Understanding potential barriers and enablers to a perioperative early phase cell therapy trial. 
Foster M, Fergusson DA, Hunniford V, Cardenas A, Castillo G, Yaworsky J, Mazer CD, Devereaux PJ, McIsaac DI, Stewart DJ, Presseau J, Lalu MM.
Cytotherapy. 2022 Apr 5:S1465-3249(21)00782-9. doi: 10.1016/j.jcyt.2021.08.008. Online ahead of print.
PMID: 35396169

Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors. 
Gage BK, Merlin S, Olgasi C, Follenzi A, Keller GM.
Cell Rep. 2022 Apr 5;39(1):110621. doi: 10.1016/j.celrep.2022.110621.
PMID: 35385743

A Human-derived Dual MRI/PET Reporter Gene System with High Translational Potential for Cell Tracking.
Shalaby N, Kelly J, Martinez F, Fox M, Qi Q, Thiessen J, Hicks J, Scholl TJ, Ronald JA.
Mol Imaging Biol. 2022 Apr;24(2):341-351. doi: 10.1007/s11307-021-01697-8. Epub 2022 Feb 10.
PMID: 35146614

Single-Cell, Single-Nucleus, and Spatial RNA Sequencing of the Human Liver Identifies Cholangiocyte and Mesenchymal Heterogeneity. 
Andrews TS, Atif J, Liu JC, Perciani CT, Ma XZ, Thoeni C, Slyper M, Eraslan G, Segerstolpe A, Manuel J, Chung S, Winter E, Cirlan I, Khuu N, Fischer S, Rozenblatt-Rosen O, Regev A, McGilvray ID, Bader GD, MacParland SA.
Hepatol Commun. 2022 Apr;6(4):821-840. doi: 10.1002/hep4.1854. Epub 2021 Nov 18.
PMID: 34792289 Free PMC article.


APRIL

Elevated numbers of infiltrating eosinophils accelerate the progression of Duchenne muscular dystrophy pathology in mdx mice.
Theret M, Rempel L, Hashimoto J, Ritso M, Tung LW, Li FF, Messing M, Hughes M, McNagny K, Rossi F.
Development. 2022 Apr 15;149(8):dev200112. doi: 10.1242/dev.200112. Epub 2022 Mar 25.
PMID: 35333325
Practical steps to identifying the research risk of pragmatic trials.
Kim SY, Kimmelman J.
Clin Trials. 2022 Mar 29:17407745211063476. doi: 10.1177/17407745211063476. Online ahead of print.
PMID: 35348360
Progressive retinal changes in pediatric multiple sclerosis.
Longoni G, Brown RA, Oyefiade A, Iruthayanathan R, Wilbur C, Shams S, Noguera A, Grover SA, O’Mahony J, Chung L, Wan MJ, Mah JK, Costello F, Arnold DL, Marrie RA, Bar-Or A, Banwell B, Mabbott D, Reginald AY, Yeh EA.
Mult Scler Relat Disord. 2022 Mar 23;61:103761. doi: 10.1016/j.msard.2022.103761. Online ahead of print.
PMID: 35349885
UM171 expansion of cord blood improves donor availability and HLA matching for all patients, including minorities.
Dumont-Lagacé M, Feghaly A, Meunier MC, Finney M, Van’t Hof W, Frenet EM, Sauvageau G, Cohen S.
Transplant Cell Ther. 2022 Mar 17:S2666-6367(22)01164-2. doi: 10.1016/j.jtct.2022.03.016. Online ahead of print.
PMID: 35311667
CEACAM1 is a novel culture-compatible surface marker of expanded long-term reconstituting hematopoietic stem cells.
Ansari U, Tomellini E, Chagraoui J, Lehnertz B, Mayotte N, Bordeleau ME, Roux PP, Sauvageau G.
Blood Adv. 2022 Mar 14:bloodadvances.2021006835. doi: 10.1182/bloodadvances.2021006835. Online ahead of print.
PMID: 35286394
Pulmonary and Neurologic Effects of Mesenchymal Stromal Cell Extracellular Vesicles in a Multifactorial Lung Injury Model.
Lithopoulos MA, Strueby L, O’Reilly M, Zhong S, Möbius MA, Eaton F, Fung M, Hurskainen M, Cyr-Depauw C, Suen C, Xu L, Collins JJP, Vadivel A, Stewart DJ, Burger D, Thébaud B.
Am J Respir Crit Care Med. 2022 Mar 14. doi: 10.1164/rccm.202012-4520OC. Online ahead of print.
PMID: 35286238
Bioabsorption of Subcutaneous Nanofibrous Scaffolds Influences the Engraftment and Function of Neonatal Porcine Islets.
Kuppan P, Kelly S, Seeberger K, Castro C, Rosko M, Pepper AR, Korbutt GS.
Polymers (Basel). 2022 Mar 11;14(6):1120. doi: 10.3390/polym14061120.
PMID: 35335450 Free PMC article.
Leveraging interacting signaling pathways to robustly improve the quality and yield of human pluripotent stem cell-derived hepatoblasts and hepatocytes.
Raggi C, M’Callum MA, Pham QT, Gaub P, Selleri S, Baratang NV, Mangahas CL, Cagnone G, Reversade B, Joyal JS, Paganelli M.
Stem Cell Reports. 2022 Mar 8;17(3):584-598. doi: 10.1016/j.stemcr.2022.01.003. Epub 2022 Feb 3.
PMID: 35120625
Modeling human yolk sac hematopoiesis with pluripotent stem cells.
Atkins MH, Scarfò R, McGrath KE, Yang D, Palis J, Ditadi A, Keller GM.
J Exp Med. 2022 Mar 7;219(3):e20211924. doi: 10.1084/jem.20211924. Epub 2021 Dec 20.
PMID: 34928315
In vivo transcriptomic profiling using cell encapsulation identifies effector pathways of systemic aging.
Mashinchian O, Hong X, Michaud J, Migliavacca E, Lefebvre G, Boss C, De Franceschi F, Le Moal E, Collerette-Tremblay J, Isern J, Metairon S, Raymond F, Descombes P, Bouche N, Muñoz-Cánoves P, Feige JN, Bentzinger CF.
Elife. 2022 Mar 4;11:e57393. doi: 10.7554/eLife.57393.
PMID: 35245177 Free PMC article.
Regulating Endogenous Neural Stem Cell Activation to Promote Spinal Cord Injury Repair.
Gilbert EAB, Lakshman N, Lau KSK, Morshead CM.
Cells. 2022 Mar 1;11(5):846. doi: 10.3390/cells11050846.
PMID: 35269466 Free PMC article. Review.
Generation of Complex Syngeneic Liver Organoids from Induced Pluripotent Stem Cells to Model Human Liver Pathophysiology.
Raggi C, Selleri S, M’Callum MA, Paganelli M.
Curr Protoc. 2022 Mar;2(3):e389. doi: 10.1002/cpz1.389.
PMID: 35263041
MITOCHONDRIA: Mitochondrial dynamics in the regulation of stem cells.
Wade S, Khacho M.
Int J Biochem Cell Biol. 2022 Mar;144:106158. doi: 10.1016/j.biocel.2022.106158. Epub 2022 Jan 19.
PMID: 35063637