Discover the science conducted by stem cell and RM researchers

JUNE

Advances in Islet Transplantation and the Future of Stem Cell-Derived Islets to Treat Diabetes. Kieffer TJ, Hoesli CA, Shapiro AMJ. Cold Spring Harb Perspect Med. 2025 May 5;15(5):a041624. doi: 10.1101/cshperspect.a041624. PMID: 39074874 Review.

Investigation of novel carboxymethyl chitosan-based bioinks for 3D bioprinting of neural tissues. Juraski AC, da Silva VA, Sharma R, Azzoni AR, Willerth SM. Biomed Mater. 2025 May 19;20(3). doi: 10.1088/1748-605X/add6f9. PMID: 40345226

Functional targeting of ILC2s and ILC3s reveals selective roles in intestinal fibrosis and homeostasis. Kabil A, Nayyar N, Xu C, Brassard J, Hill LA, Shin SB, Chopra S, Lo B, Li Y, Bal M, Theret M, Rossi FMV, Underhill TM, Hughes MR, McNagny KM. J Exp Med. 2025 Jul 7;222(7):e20241671. doi: 10.1084/jem.20241671. Epub 2025 May 28. PMID: 40434419

A multi-kingdom genetic barcoding system for precise clone isolation. Ishiguro S, Ishida K, Sakata RC, Ichiraku M, Takimoto R, Yogo R, Kijima Y, Mori H, Tanaka M, King S, Tarumoto S, Tsujimura T, Bashth O, Masuyama N, Adel A, Toyoshima H, Seki M, Oh JH, Archambault AS, Nishida K, Kondo A, Kuhara S, Aburatani H, Klein Geltink RI, Yamamoto T, Shakiba N, Takashima Y, Yachie N. Nat Biotechnol. 2025 May 21. doi: 10.1038/s41587-025-02649-1. Online ahead of print. PMID: 40399693

Human pluripotent stem cell-based cardiac repair: Lessons learned and challenges ahead. Montague EC, Ozcan B, Sefton E, Wulkan F, Alibhai FJ, Laflamme MA. Adv Drug Deliv Rev. 2025 May 5;222:115594. doi: 10.1016/j.addr.2025.115594. Online ahead of print. PMID: 40334814 Review.

Cell therapy with human IL-10-producing ILC2s enhances islet function and inhibits allograft rejection. Colpitts SJ, Jegatheeswaran S, Oakie A, Mashhouri S, Sachewsky N, Murshed H, Mathews JA, Reid KT, Misra PS, Fung VCW, Reichman TW, Nostro MC, Verchere CB, Levings MK, Crome SQ. Am J Transplant. 2025 May 22:S1600-6135(25)00280-1. doi: 10.1016/j.ajt.2025.05.023. Online ahead of print. PMID: 40412656

Allogeneic Hematopoietic Cell Transplant for B-Cell Lymphomas in the Era of Novel Cellular Therapies: Experience from a Tertiary Canadian Center. Castonguay M, Roy J, Claveau JS, Lachance S, Delisle JS, Kiss T, Cohen S, Fleury I, Mollica L, Ahmad I, Bambace N, Bernard L, Roy DC, Sauvageau G, Veilleux O. Curr Oncol. 2025 May 20;32(5):285. doi: 10.3390/curroncol32050285. PMID: 40422544 Free PMC article.

Maternal autoantibodies to the sodium potassium pump α1 subunit AT1A1 and fetal autoimmune congenital heart block: a case-control study. Benjamin S, Vi L, Chatterjee D, Jaeggi ET, Ruffatti A, Hiraki LT, Sepiashvili L, Laskin CA, Fatah M, Tonello M, Dominguez D, Ng L, Lohbihler M, Luchessi AD, Hogarth K, Daoud A, Maynes JT, Protze S, Hamilton RM. Lancet Rheumatol. 2025 May 21:S2665-9913(25)00092-X. doi: 10.1016/S2665-9913(25)00092-X. Online ahead of print. PMID: 40412415

Importin-alpha transports Norrin to the nucleus to promote proliferation and Notch signaling in glioblastoma stem cells. El-Sehemy A, Tachibana N, Ortin-Martinez A, Ringuette D, Coyaud É, Raught B, Dirks P, Wallace VA. Oncogene. 2025 May 27. doi: 10.1038/s41388-025-03427-8. Online ahead of print. PMID: 40425833

MAY

Dissecting cardiovascular disease-associated noncoding genetic variants using human iPSC models. Dababneh SF, Babini H, Jiménez-Sábado V, Teves SS, Kim KH, Tibbits GF. Stem Cell Reports. 2025 Apr 8;20(4):102467. doi: 10.1016/j.stemcr.2025.102467. Epub 2025 Mar 20. PMID: 40118058 Review.

Advances in Cell Replacement Therapies for Diabetes. Hering BJ, Rickels MR, Bellin MD, Millman JR, Tomei AA, García AJ, Shirwan H, Stabler CL, Ma M, Yi P, Luo X, Tang Q, Ramachandran S, Oberholzer J, Ricordi C, Kieffer TJ, Shapiro AMJ. Diabetes. 2025 Apr 24:db250037. doi: 10.2337/db25-0037. Online ahead of print. PMID: 40272266

Optimizing electrical field stimulation parameters reveals the maximum contractile function of human skeletal muscle microtissues. Tiper Y, Xie Z, Hofemeier A, Lad H, Luber M, Krawetz R, Betz T, Zimmermann WH, Morton AB, Segal SS, Gilbert PM.Am J Physiol Cell Physiol. 2025 Apr 1;328(4):C1160-C1176. doi: 10.1152/ajpcell.00308.2024. Epub 2025 Feb 28. PMID: 40019026

Timing neural development and regeneration. Blackshaw S, Cayouette M. Curr Opin Neurobiol. 2025 Apr;91:102976. doi: 10.1016/j.conb.2025.102976. Epub 2025 Feb 25. PMID: 40010202 Review.

A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy. Benvenisty N, Draper JS, Gokhale PJ, Healy L, Hewitt Z, Hursh D, Hodgson A, Ludwig TE, Mah N, McClelland SE, Mennecozzi M, Merkle FT, Mountford JC, Pera M, Prigione A, Rodriguez TA, Rossi A, Rouhani FJ, Saeb-Parsy K, Selfa Aspiroz L, Shakiba N, Spits C, Tonge PD, Barbaric I. Cell Stem Cell. 2025 Apr 3;32(4):508-512. doi: 10.1016/j.stem.2025.03.003. PMID: 40185071

Expanding the neuroimmune research toolkit with in vivo brain organoid technologies. Tian A, Bhattacharya A, Muffat J, Li Y. Dis Model Mech. 2025 Apr 1;18(4):dmm052200. doi: 10.1242/dmm.052200. Epub 2025 Apr 15. PMID: 40231345 Free PMC article. Review.

Recent Advances in Modeling Tissues Using 3D Bioprinted Nanocellulose Bioinks. Walters-Shumka JP, Cheng C, Jiang F, Willerth SM. ACS Biomater Sci Eng. 2025 Apr 14;11(4):1882-1896. doi: 10.1021/acsbiomaterials.4c01902. Epub 2025 Mar 10. PMID: 40065192 Review.

CAR Treg synergy with anti-CD154 promotes infectious tolerance and dictates allogeneic heart transplant acceptance. Durgam SS, Rosado-Sánchez I, Yin D, Speck M, Mojibian M, Sayin I, Hynes GE, Alegre ML, Levings MK, Chong AS. JCI Insight. 2025 Apr 8;10(7):e188624. doi: 10.1172/jci.insight.188624. PMID: 40197364 Free PMC article.

Scientometric analysis of evolution in sex-specific MSC therapy for cardiovascular diseases. Verma E, Gupta M, Sierhuis R, Dhingra S. Biochim Biophys Acta Mol Basis Dis. 2025 Apr 29;1871(6):167878. doi: 10.1016/j.bbadis.2025.167878. Online ahead of print. PMID: 40311883