Discover the science conducted by stem cell and RM researchers

MAY

Nanothin Conformal Coating with Poly(N-vinylpyrrolidone) and Tannic Acid (PVPON/TA) Preserves Murine and Human Pancreatic Islets Function. 
Polishevska K, Kelly S, Kuppan P, Seeberger KL, Aggarwal S, Paramor J, Unsworth LD, Tse HM, Korbutt GS, Pepper AR.
Pharmaceutics. 2023 Apr 4;15(4):1137. doi: 10.3390/pharmaceutics15041137.
PMID: 37111623 Free PMC article.

An International Society for Cell and Gene Therapy Mesenchymal Stromal Cells (MSC) Committee perspectives on International Standards Organization/Technical Committee 276 Biobanking Standards for bone marrow-MSCs and umbilical cord tissue-derived MSCs for research purposes. 
Viswanathan S, Blanc KL, Ciccocioppo R, Dagher G, Filiano AJ, Galipeau J, Krampera M, Krieger L, Lalu MM, Nolta J, Rodriguez Pardo VM, Shi Y, Tarte K, Weiss DJ, Martin I.
Cytotherapy. 2023 May 5:S1465-3249(23)00100-7. doi: 10.1016/j.jcyt.2023.04.005. Online ahead of print.
PMID: 37149800

Buffering of transcription rate by mRNA half-life is a conserved feature of Rett syndrome models. 
Rodrigues DC, Mufteev M, Yuki KE, Narula A, Wei W, Piekna A, Liu J, Pasceri P, Rissland OS, Wilson MD, Ellis J.
Nat Commun. 2023 Apr 5;14(1):1896. doi: 10.1038/s41467-023-37339-6.
PMID: 37019888 Free PMC article.

Single cell transcriptomic atlas of lung microvascular regeneration after targeted endothelial cell ablation. 
Godoy RS, Cober ND, Cook DP, McCourt E, Deng Y, Wang L, Schlosser K, Rowe K, Stewart DJ.
Elife. 2023 Apr 20;12:e80900. doi: 10.7554/eLife.80900. Online ahead of print.
PMID: 37078698

Strengths, gaps, and future directions on the landscape of ethics-related research for spinal cord injury. 
Nuechterlein A, Feng L, Yehia A, Illes J.
Spinal Cord. 2023 Apr 18. doi: 10.1038/s41393-023-00897-z. Online ahead of print.
PMID: 37072509 Review.

Understanding neural development and diseases using CRISPR screens in human pluripotent stem cell-derived cultures. 
Ahmed M, Muffat J, Li Y.
Front Cell Dev Biol. 2023 Apr 10;11:1158373. doi: 10.3389/fcell.2023.1158373. eCollection 2023.
PMID: 37101616 Free PMC article. Review.

Mechanisms of Cardiac Repair in Cell Therapy. 
Collet BC, Davis DR.
Heart Lung Circ. 2023 Apr 6:S1443-9506(23)00122-1. doi: 10.1016/j.hlc.2023.01.019. Online ahead of print.
PMID: 37031061

Development and Function of FOXP3 + Regulators of Immune Responses. 
Golzari-Sorkheh M, Zúñiga-Pflücker JC.
Clin Exp Immunol. 2023 Apr 22:uxad048. doi: 10.1093/cei/uxad048. Online ahead of print.
PMID: 37085947

The Effect of Crosslinking Density on Nasal Chondrocytes’ Redifferentiation. 
Lan X, Ma Z, Kunze M, Mulet-Sierra A, Osswald M, Ansari K, Seikaly H, Boluk Y, Adesida AB.
Ann Biomed Eng. 2023 Apr 1. doi: 10.1007/s10439-023-03184-3. Online ahead of print.
PMID: 37005947

Heat shock transcription factors demonstrate a distinct mode of interaction with mitotic chromosomes. 
Price RM, Budzyński MA, Shen J, Mitchell JE, Kwan JZJ, Teves SS.
Nucleic Acids Res. 2023 Apr 28:gkad304. doi: 10.1093/nar/gkad304. Online ahead of print.
PMID: 37114996

Single-nuclei RNA Profiling Reveals Disruption of Adipokine and Inflammatory Signaling in Adipose Tissue of Burn Patients. 
Knuth CM, Ricciuti Z, Barayan D, Rehou S, Abdullahi A, de Brito Monteiro L, Jeschke MG.
Ann Surg. 2023 Apr 14. doi: 10.1097/SLA.0000000000005880. Online ahead of print.
PMID: 37057618

An Automation Workflow for High-Throughput Manufacturing and Analysis of Scaffold-Supported 3D Tissue Arrays. 
Cao R, Li NT, Latour S, Cadavid JL, Tan C, Forman A, Jackson HW, McGuigan AP.
Adv Healthc Mater. 2023 Apr 22:e2202422. doi: 10.1002/adhm.202202422. Online ahead of print.
PMID: 37086259

Selecting Normalizers for MicroRNA RT-qPCR Expression Analysis in Murine Preimplantation Embryos and the Associated Conditioned Culture Media. 
Hawke DC, Watson AJ, Betts DH.
J Dev Biol. 2023 Apr 4;11(2):17. doi: 10.3390/jdb11020017.
PMID: 37092479 Free PMC article.

Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity. 
O’Brien C, Ling T, Berman JM, Culp-Hill R, Reisz JA, Rondeau V, Jahangiri S, St-Germain J, Macwan V, Astori A, Zeng A, Hong JY, Li M, Yang M, Jana S, Gamboni F, Tsao E, Liu W, Dick JE, Lin H, Melnick A, Tikhonova A, Arruda A, Minden MD, Raught B, D’Alessandro A, Jones CL.
Haematologica. 2023 Apr 6. doi: 10.3324/haematol.2022.281894. Online ahead of print.
PMID: 37021547

North American Clinical Trials Network for Spinal Cord Injury Registry: Methodology and Analysis.
Toups EG, Ugiliweneza B, Howley SP, Neal CJ, Harrop JS, Guest J, Grossman R, Fehlings MG.
J Neurotrauma. 2023 Apr 26. doi: 10.1089/neu.2022.0403. Online ahead of print.
PMID: 37125443

APRIL

PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing. 
Cikes D, Elsayad K, Sezgin E, Koitai E, Ferenc T, Orthofer M, Yarwood R, Heinz LX, Sedlyarov V, Miranda ND, Taylor A, Grapentine S, Al-Murshedi F, Abot A, Weidinger A, Kutchukian C, Sanchez C, Cronin SJF, Novatchkova M, Kavirayani A, Schuetz T, Haubner B, Haas L, Hagelkruys A, Jackowski S, Kozlov A, Jacquemond V, Knauf C, Superti-Furga G, Rullman E, Gustafsson T, McDermot J, Lowe M, Radak Z, Chamberlain JS, Bakovic M, Banka S, Penninger JM.
Nat Metab. 2023 Mar;5(3):495-515. doi: 10.1038/s42255-023-00766-2. Epub 2023 Mar 20.
PMID: 36941451

Affinity-controlled release of rod-derived cone viability factor enhances cone photoreceptor survival. 
Teal CJ, Ho MT, Huo L, Harada H, Bahlmann LC, Léveillard T, Monnier PP, Ramachandran A, Shoichet MS.
Acta Biomater. 2023 Apr 15;161:37-49. doi: 10.1016/j.actbio.2023.03.003. Epub 2023 Mar 8.
PMID: 36898472

Incorporating Combinatorial Approaches to Encourage Targeted Neural Stem/Progenitor Cell Integration Following Transplantation in Spinal Cord Injury. 
Pieczonka K, Fehlings MG.
Stem Cells Transl Med. 2023 Mar 9:szad008. doi: 10.1093/stcltm/szad008. Online ahead of print.
PMID: 36892546

Hic1 identifies a specialized mesenchymal progenitor population in the embryonic limb responsible for bone superstructure formation. 
Arostegui M, Scott RW, Underhill TM.
Cell Rep. 2023 Mar 31;42(4):112325. doi: 10.1016/j.celrep.2023.112325. Online ahead of print.
PMID: 37002923

Visualizing cell-cell communication using synthetic notch activated MRI. 
Wang T, Chen Y, Nystrom NN, Liu S, Fu Y, Martinez FM, Scholl TJ, Ronald JA.
Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2216901120. doi: 10.1073/pnas.2216901120. Epub 2023 Mar 9.
PMID: 36893267

Stem cell therapies for neonatal lung diseases: Are we there yet? 
Thébaud B.
Semin Perinatol. 2023 Mar 12:151724. doi: 10.1016/j.semperi.2023.151724. Online ahead of print.
PMID: 36967368

Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion. 
Lamarche C, Ward-Hartstonge K, Mi T, Lin DTS, Huang Q, Brown A, Edwards K, Novakovsky GE, Qi CN, Kobor MS, Zebley CC, Weber EW, Mackall CL, Levings MK.
Proc Natl Acad Sci U S A. 2023 Apr 4;120(14):e2219086120. doi: 10.1073/pnas.2219086120. Epub 2023 Mar 27.
PMID: 36972454

RNA Polymerase II transcription independent of TBP. 
Kwan JZJ, Nguyen TF, Uzozie AC, Budzynski MA, Cui J, Lee JMC, Van Petegem F, Lange PF, Teves SS.
Elife. 2023 Mar 30;12:e83810. doi: 10.7554/eLife.83810. Online ahead of print.
PMID: 36995326

Extracellular vesicle microRNA and protein cargo profiling in three clinical-grade stem cell products reveals key functional pathways. 
Vaka R, Parent S, Risha Y, Khan S, Courtman D, Stewart DJ, Davis DR.
Mol Ther Nucleic Acids. 2023 Mar 9;32:80-93. doi: 10.1016/j.omtn.2023.03.001. eCollection 2023 Jun 13.
PMID: 36969553 Free PMC article.

A Multi-Stage Bioprocess for the Expansion of Rodent Skin-Derived Schwann Cells in Computer-Controlled Bioreactors. 
Walsh T, Abraham B, Chu TH, Biernaskie J, Midha R, Kallos MS.
Int J Mol Sci. 2023 Mar 8;24(6):5152. doi: 10.3390/ijms24065152.
PMID: 36982227 Free PMC article.

A systematic assessment of preclinical multilaboratory studies and a comparison to single laboratory studies. 
Hunniford VT, Grudniewicz A, Fergusson DA, Montroy J, Grigor E, Lansdell C, Lalu MM; Canadian Critical Care Translational Biology Group.
Elife. 2023 Mar 9;12:e76300. doi: 10.7554/eLife.76300. Online ahead of print.
PMID: 36892457

3D Printed Hydrogel Microneedle Arrays for Interstitial Fluid Biomarker Extraction and Colorimetric Detection. 
Razzaghi M, Seyfoori A, Pagan E, Askari E, Hassani Najafabadi A, Akbari M.
Polymers (Basel). 2023 Mar 10;15(6):1389. doi: 10.3390/polym15061389.
PMID: 36987171 Free PMC article.