Discover the science conducted by stem cell and RM researchers

SEPTEMBER

Navigating challenges in human pluripotent stem cell-derived islet therapy for type 1 diabetes. Usama M, Deng Y, Chen Y, Milland T, Malleshaiah M, Aghazadeh Y. Front Immunol. 2025 Aug 4;16:1625439. doi: 10.3389/fimmu.2025.1625439. eCollection 2025.PMID: 40831568 Free PMC article. Review.

REST/NRSF Preserves muscle stem cell identity by repressing alternate cell fate. Sahinyan K, Blackburn DM, Simon MM, Lazure F, Kwan T, Wilson DH, Vahidyeganeh M, Alsadi N, von Maltzahn J, Yamada Y, Jahani-Asl A, Bourque G, Rudnicki MA, Soleimani VD. Nat Commun. 2025 Aug 12;16(1):7487. doi: 10.1038/s41467-025-62758-y.PMID: 40796549 Free PMC article.

Protocol for dual-optical mapping of voltage and calcium sensors in human pluripotent stem cell-derived cardiomyocytes. Alibhai FJ, Masoumi A, Kim HJ, Kim N, Kim W, Gomez-Garcia J, Lee P, Laflamme MA. STAR Protoc. 2025 Aug 23;6(3):104044. doi: 10.1016/j.xpro.2025.104044. Online ahead of print.PMID: 40849912 Free PMC article.

Human iPSCs-derived mesenchymal stem cells promote skin regeneration and burn wound healing. Farahat M, Brosset S, Chen Y, Aijaz A, Rix G, Challagundla B, Elloso M, Hutter MF, Rogers IM, Jeschke MG. NPJ Regen Med. 2025 Aug 30;10(1):40. doi: 10.1038/s41536-025-00427-w.PMID: 40885782 Free PMC article.

Modelling the liver’s regenerative capacity across different clinical conditions. Nguyen-Lefebvre AT, Ghosh S, Baciu C, Hasjim BJ, Naimimohasses S, Oldani G, Pasini E, Brudno M, Selzner N, Wrana J, Bhat M. JHEP Rep. 2025 May 30;7(8):101465. doi: 10.1016/j.jhepr.2025.101465. eCollection 2025 Aug. PMID: 40704068 Free PMC article.

 Satellite Cells in Regeneration and Disease. Esper ME, Saber J, Rudnicki MA. Cold Spring Harb Perspect Biol. 2025 Aug 18:a041474. doi: 10.1101/cshperspect.a041474. Online ahead of print. PMID: 40825664

Biosynthetic Collagen-Analog Hydrogels Stimulate Endogenous Regrowth of Rabbit Corneas: A Pilot Study. Timmerman I, Robert MC, Vergneau-Grosset C, Juette T, Benito J, Garbin M, Zamani-Roudbaraki M, Moradi M, Goodarzi H, Boutopoulos C, Benoit-Biancamano MO, Griffith M, Vanore M. Vet Sci. 2025 Aug 21;12(8):785. doi: 10.3390/vetsci12080785.PMID: 40872735 Free PMC article.

AI-Driven Quality Monitoring and Control in Stem Cell Cultures: A Comprehensive Review. Singh R, Orimi HE, Pedabaliyarasimhuni PKR, Hoesli CA, Chioua M. Biotechnol J. 2025 Aug;20(8):e70100. doi: 10.1002/biot.70100.PMID: 40785233 Free PMC article. Review.

Scientometric analysis of evolution in sex-specific MSC therapy for cardiovascular diseases. Verma E, Gupta M, Sierhuis R, Dhingra S. Biochim Biophys Acta Mol Basis Dis. 2025 Aug;1871(6):167878. doi: 10.1016/j.bbadis.2025.167878. Epub 2025 Apr 29. PMID: 40311883 Free article. Review.

A molecular systems architecture of the mesenchymal stromal cell microenvironment. Ayyadurai VAS, Deonikar P, Radhakrishnan V, Keating A. Stem Cells. 2025 Aug 22;43(9):sxaf042. doi: 10.1093/stmcls/sxaf042.PMID: 40843515 Free PMC article.

The Role of Mesenchymal Stromal Cells in the Treatment of Bronchopulmonary Dysplasia: A Multi-Prong Approach for a Heterogeneous Disease. Deguise MO, Thébaud B. Compr Physiol. 2025 Aug;15(4):e70038. doi: 10.1002/cph4.70038.PMID: 40853849 Free PMC article. Review.

Development of a tissue-specific bioscaffold for intestinal stem cell culture. Kakar S, Derouet MF, Zhang L, Gillis CJ, Larsen F, Paul A, Flynn LE, Asfaha S. PLoS One. 2025 Aug 6;20(8):e0328898. doi: 10.1371/journal.pone.0328898. eCollection 2025.PMID: 40768435 Free PMC article.

In silico modeling of directed differentiation of induced pluripotent stem cells to definitive endoderm. Mostofinejad A, Romero DA, Brinson D, Waddell TK, Karoubi G, Amon CH. PLoS Comput Biol. 2025 Aug 21;21(8):e1013407. doi: 10.1371/journal.pcbi.1013407. Online ahead of print.PMID: 40839670 Free article.

Micropocket-Based Differentiation System to Streamline and Scale Stem Cell-Derived Pancreatic Islet Production. O’Brien S, Li C, Trana R, Hoesli C, Moraes C. ACS Biomater Sci Eng. 2025 Aug 11;11(8):5096-5106. doi: 10.1021/acsbiomaterials.5c00372. Epub 2025 Jul 23.PMID: 40700651

Tissue Engineering Nasal Cartilage Grafts with Three-Dimensional Printing: A Comprehensive Review. Perry AC, Adesida AB. Tissue Eng Part B Rev. 2025 Aug;31(4):331-356. doi: 10.1089/ten.TEB.2024.0187. Epub 2024 Oct 22.PMID: 39311456 Review.

AUGUST

Bioactive lipid mediator class switching regulates myogenic cell progression and muscle regeneration. Fabre P, Molina T, Larose J, Greffard K, Généreux-Gamache G, Deprez A, Mokhtari I, Pellerito O, Duchesne E, Dort J, Bilodeau JF, Dumont NA. Nat Commun. 2025 Jul 1;16(1):5578. doi: 10.1038/s41467-025-60586-8. PMID: 40595516 Free PMC article.

GDF11-secreting cell transplant efficiently ameliorates age-related pulmonary fibrosis. Guo L, Duchesneau P, Jong ED, Sawula E, Li C, Waddell TK, Nagy A. Mol Ther. 2025 Jul 16:S1525-0016(25)00539-8. doi: 10.1016/j.ymthe.2025.07.003. Online ahead of print. PMID: 40676836

A dermis-on-a-chip model for compound screening. Abdo D, Zhao Y, Okhovatian S, Jiménez Vargas LF, Wagner KT, Shakeri A, Vosoughi D, Radisic M. Mater Today Bio. 2025 Jul 18;34:102111. doi: 10.1016/j.mtbio.2025.102111. eCollection 2025 Oct. PMID: 40740248 Free PMC article.

Protocol for 3D Bioprinting a Co-culture Skin Model Using a Natural Fibrin-Based Bioink as an Infection Model. Díaz GY, Perry MA, Cárdenas LS, Da Silva VA, Scheck K, Tschofen SA, Tuffs SW, Willerth SM. Bio Protoc. 2025 Jul 20;15(14):e5380. doi: 10.21769/BioProtoc.5380. eCollection 2025 Jul 20. PMID: 40741391 Free PMC article.

Advances in Cell Replacement Therapies for Diabetes. Hering BJ, Rickels MR, Bellin MD, Millman JR, Tomei AA, García AJ, Shirwan H, Stabler CL, Ma M, Yi P, Luo X, Tang Q, Ramachandran S, Oberholzer J, Ricordi C, Kieffer TJ, Shapiro AMJ. Diabetes. 2025 Jul 1;74(7):1068-1077. doi: 10.2337/db25-0037. PMID: 40272266 Free PMC article. Review.

Mesenchymal stromal cells: an update. Lee OJ, Keating A. Curr Opin Hematol. 2025 Sep 1;32(5):270-278. doi: 10.1097/MOH.0000000000000887. Epub 2025 Jul 16. PMID: 40668265 Review.

CCL22-expressing Stem Cell-derived Islet Grafts Recruit Regulatory T Cells in Mice. Filatov E, Sasaki S, Haque M, Kar S, Fung VCW, Mojibian M, Krentz NAJ, MacDonald KN, Salim K, Soukhatcheva G, Dai DL, Orban PC, Verchere CB, Levings MK, Lynn FC. Transplantation. 2025 Jul 11. doi: 10.1097/TP.0000000000005463. Online ahead of print. PMID: 40644632

Impact of culture vessel materials on biomanufacturing of dendritic cell-based immunotherapies in closed systems. Tian JJ, Ebrahimi Orimi H, Fekete N, Drolet N, Campbell K, Tremblay ML, Peltier L, Laneuville P, Girard-Lauriault PL, Hoesli CA. Biomater Sci. 2025 Jul 7. doi: 10.1039/d5bm00245a. Online ahead of print. PMID: 40620080 Review.

Novel Immune Response Evasion Strategy to Redose Adeno-associated Viral Vectors and Prolong Survival in Surfactant Protein-B-Deficient Mice. Kang MH, Thomas SP, Westley C, Blouin T, Xu L, Chan YK, Lisk E, Allen SE, Vadivel A, Nangle K, Ramamurthy J, Pei Y, Lewis LA, Chiang JJ, Romeo MJ, Vaena S, O’Quinn EC, Schrecker HD, Langdon CG, Nietert PJ, Church GM, Whitsett JA, Wootton SK, Thébaud B. Am J Respir Cell Mol Biol. 2025 Jul;73(1):120-134. doi: 10.1165/rcmb.2024-0247OC. PMID: 39805087

Bacterial ADP-heptose triggers stem cell regeneration in the intestinal epithelium following injury. Goyal S, Guo CX, Singh O, Ranger A, Harrigan CF, Meade J, Luchak A, Tsang DK, Gaisano HY, Gao N, Yuzwa SA, Wrana JL, Philpott DJ, Gray-Owen SD, Girardin SE. Cell Stem Cell. 2025 Jul 4:S1934-5909(25)00231-0. doi: 10.1016/j.stem.2025.06.009. Online ahead of print. PMID: 40651470

Computer vision to predict cell seeding coverage in re-endothelialized mouse lungs. Paciocco J, Hasan A, Chan J, Taniguchi D, Amon C, Karoubi G, Bazylak A. Sci Rep. 2025 Jul 19;15(1):26236. doi: 10.1038/s41598-025-11272-8. PMID: 40683991 Free PMC article.

Thermoresponsive BrushGel Microcarriers for Efficient Cell Expansion and Enzyme-Reduced Harvesting. Askari E, Barough MS, Seyfoori A, Razzaghi M, Ninan JA, Murray ABP, Salkhordeh M, Tan Y, Mei SHJ, Akbari M. Adv Healthc Mater. 2025 Jul 14:e2404538. doi: 10.1002/adhm.202404538. Online ahead of print. PMID: 40653897

Immunomodulation With Local, Sustained Delivery of Pituitary Adenylate Cyclase Activating Polypeptide Results in Improved Functional Recovery in Stroke-Injured Mice. Ho E, Li DX, Cui H, Akbar D, Siu R, Morshead CM, Chatenet D, Shoichet MS. Adv Healthc Mater. 2025 Jul 11:e2500765. doi: 10.1002/adhm.202500765. Online ahead of print. PMID: 40643056

p66Shc deletion confers apoptotic resistance to loss of EGFR-ERK signalling in neural stem cells. Powell AM, Cumming RC, Betts DH. Cell Death Dis. 2025 Jul 1;16(1):479. doi: 10.1038/s41419-025-07778-8. PMID: 40593476 Free PMC article.

Micropocket-Based Differentiation System to Streamline and Scale Stem Cell-Derived Pancreatic Islet Production. O’Brien S, Li C, Trana R, Hoesli C, Moraes C. ACS Biomater Sci Eng. 2025 Jul 23. doi: 10.1021/acsbiomaterials.5c00372. Online ahead of print. PMID: 40700651

Generation of a new human iPSC cell line (UOMi010-A) from a patient with hypophosphatasia. Srivastava A, Walker D, Uzonna J, Rockman-Greenberg C, Dhingra S. Stem Cell Res. 2025 Jul 11;87:103775. doi: 10.1016/j.scr.2025.103775. Online ahead of print. PMID: 40652798

Derivation and Culture of Enriched Phrenic-Like Motor Neurons From Human iPSCs. Thiry L, Sirois J, Durcan TM, Stifani S. Bio Protoc. 2025 Jul 5;15(13):e5363. doi: 10.21769/BioProtoc.5363. eCollection 2025 Jul 5. PMID: 40655414 Free PMC article.

Inflammation sends old muscle stem cells into a rusty meltdown. Ashekyan O, Rudnicki MA. Nat Aging. 2025 Jul 25. doi: 10.1038/s43587-025-00937-8. Online ahead of print PMID: 40715665 No abstract available.