Découvrez les recherches menées actuellement dans le domaine des cellules souches et de la MR

Les publications scientifiques sont présentées dans la langue dans laquelle elles ont été soumises.

DECEMBER

Ex vivo perfusion recellularization of acellular rat hindlimbs for vascular composite allotransplantation. Adil A, Biniazan F, Shamoun V, Karoubi G, Haykal S. Sci Rep. 2025 Nov 21;15(1):41231. doi: 10.1038/s41598-025-25223-w.PMID: 41272043 Free PMC article.

TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells. Liu Y, Schüler SC, Dumontier S, Balg F, Bedard S, Desgeorges T, Feige JN, Boudreault PL, Bentzinger CF. Nat Commun. 2025 Nov 21. doi: 10.1038/s41467-025-66582-2. Online ahead of print.PMID: 41271737 Free article.

CD33 epitope editing unlocks UM171-expanded cord blood grafts for AML immunotherapy. Lehnertz B, Langouët M, Corneau S, MacRae T, Joe M, Schmidt EN, Spinella JF, Mayotte N, Moore S, Tellechea MF, Boivin I, Papineau L, Rojas-Sutterlin S, Tual M, Cortes CJ, Chagraoui J, Tomellini E, Desse V, Gagnon E, Macauley MS, Sauvageau G. Mol Ther. 2025 Nov 10:S1525-0016(25)00950-5. doi: 10.1016/j.ymthe.2025.11.010. Online ahead of print.PMID: 41220177

Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis. Esper ME, Lin AYT, Bennett D, Rudnicki MA. Nat Commun. 2025 Nov 14;16(1):10031. doi: 10.1038/s41467-025-64999-3.PMID: 41238533 Free PMC article.

USH2A-Mutated Human Retinal Organoids Model Rod-Cone Dystrophy. Ashworth KE, Zhang J, D’Amata C, Héon E, Ballios BG. Invest Ophthalmol Vis Sci. 2025 Nov 3;66(14):2. doi: 10.1167/iovs.66.14.2.PMID: 41182029 Free PMC article.

Identifying challenges and enablers to engaging patients in preclinical laboratory research: an interview study. Foster M, Fergusson DA, Thompson E, Hunniford V, Scott T, Daniels S, Richards DP, Messner P, Hendrick K, Sullivan P, Mendelson AA, Macala KF, Fiest KM, Crawley AM, Thébaud B, Nicholls SG, Séguin CA, Fox G, Presseau J, Lalu MM. Res Involv Engagem. 2025 Nov 28. doi: 10.1186/s40900-025-00818-9. Online ahead of print.PMID: 41316501 Free article.

3D-printed sacrificial molds for high-resolution, patient-specific hydrogel heart valve engineering.Rioux Y, Fradette J, Hayward CJ, Séguin V, Bégin-Drolet A, Ruel J. Biofabrication. 2025 Nov 28;18(1). doi: 10.1088/1758-5090/ae1dd0.PMID: 41213244

Epigenomic alterations and neural development anomalies in induced pluripotent stem cells from sporadic Alzheimer’s disease. Katbe A, Hanna R, Flamier A, Serhani D, Hamam R, Barabino A, Tavares E, Héon É, Bernier G. Development. 2025 Nov 26:dev.204910. doi: 10.1242/dev.204910. Online ahead of print.PMID: 41293951

Enhanced fracture repair in p21^-/- mice is mediated through increased callus mineralization. Olsen A, Premnath P, Brunet S, Larijani L, Manske SL, Ferrie L, Duncan NA, Rancourt DE, Marcucio RS, Krawetz R. Bone. 2025 Nov 18;203:117732. doi: 10.1016/j.bone.2025.117732. Online ahead of print.PMID: 41260533 Free article.

Teratoma-free cartilage regeneration using p21-/- iPSCs engineered with iCasp9. Larijani L, Rancourt D, Krawetz RJ. Stem Cells Transl Med. 2025 Nov 14;14(11):szaf056. doi: 10.1093/stcltm/szaf056.PMID: 41259786 Free PMC article.

Protocol for the generation of three-dimensional micropatterned neuroepithelial tissues using hPSCs, bioprinting, and matrix scaffolds. Wong KKL, Imani Farahani N, Allen G, Minhas A, Julian LM. STAR Protoc. 2025 Nov 11;6(4):104196. doi: 10.1016/j.xpro.2025.104196. Online ahead of print.PMID: 41223057 Free PMC article.

Alzheimer’s disease PSEN-2 N141I mutation reveals altered and shear-sensitive brain endothelial cell-like phenotype in human iPSC-derived models. Takeuchi LE, Lam J, Simmons CA. Acta Neuropathol Commun. 2025 Nov 11;13(1):231. doi: 10.1186/s40478-025-02152-3.PMID: 41219801 Free PMC article.

NOVEMBRE

GDF11-secreting cell transplant efficiently ameliorates age-related pulmonary fibrosis. Guo L, Duchesneau P, Jong ED, Sawula E, Li C, Waddell TK, Nagy A. Mol Ther. 2025 Oct 1;33(10):5131-5148. doi: 10.1016/j.ymthe.2025.07.003. Epub 2025 Jul 16.PMID: 40676836 Free article.

Culture Strategy Determines the Differentiation Status of Sweat Gland Cells. De Koninck H, Ferland K, Barbier MA, Larouche D, Germain L. Cells. 2025 Oct 21;14(20):1643. doi: 10.3390/cells14201643.PMID: 41148857 Free PMC article.

Generation of two human induced pluripotent stem cell lines from patient-derived fibroblasts with severe congenital defects of the vertebrae and neural tube. Lee JA, Conrad JV, Rusteika M, Drissi TH, Zhang T, Liu S, Singla S, Willetts L, Semper C, Rancourt D, Chu LF. Stem Cell Res. 2025 Oct;88:103837. doi: 10.1016/j.scr.2025.103837. Epub 2025 Sep 14.PMID: 40997543 Free article.

The marketing of « stem cell » supplements on Amazon.com: Assessing alignment with regulatory frameworks in the United States and Canada. Marcon AR, Zenone M, Boniface V, Sigfstead S, Murdoch B, Caulfield T. Stem Cell Reports. 2025 Oct 9:102675. doi: 10.1016/j.stemcr.2025.102675. Online ahead of print.PMID: 41072411 Free article.

Study of angiogenic cell therapy for progressive pulmonary arterial hypertension: intervention with repeat dosing of eNOS-enhanced EPCs: the SAPPHIRE trial. Stewart DJ, Mehta S, Chandy G, Hirani N, Granton J, Hambly N, Swiston J, Danovitch K, Sabri E, Giulivi A, Courtman DW, Fergusson DA. J Heart Lung Transplant. 2025 Oct;44(10):1663-1667. doi: 10.1016/j.healun.2025.05.012. Epub 2025 May 28.PMID: 40446884 Free article. Clinical Trial.

Collagen Analogs Promote Tissue Regeneration in HSV-1-Infected Corneas in Animal Models. Buznyk O, Goodarzi H, Gómez Laguna J, Reddy J, Liszka A, Edin E, Boutopoulos C, Chodosh J, Islam MM, Griffith M. J Funct Biomater. 2025 Oct 9;16(10):377. doi: 10.3390/jfb16100377.PMID: 41149723 Free PMC article.

High IL1R1 expression predicts poor survival and benefit from stem cell transplant in intermediate-risk acute myeloid leukemia from the Leucegene cohort. Richard-Carpentier G, Béliveau F, Lacoste S, Khakipoor B, Lisi V, Vladovsky M, Marquis M, Spinella JF, Gendron P, Lemieux S, Lavallée VP, Sauvageau G, Hébert J. Biomark Res. 2025 Oct 23;13(1):133. doi: 10.1186/s40364-025-00827-6.PMID: 41131586 Free PMC article.

Preterm Birth Conditions Alter Muscle Stem Cells and Their Niche, Causing Lasting Impairments in Muscle Regeneration and Function. Deprez A, Molina T, Cagnone G, Garcia P, Leclerc S, Cloutier A, Desaulniers R, Ellezam B, Nuyt AM, Dumont NA .J Cachexia Sarcopenia Muscle. 2025 Oct;16(5):e70058. doi: 10.1002/jcsm.70058.PMID: 40955870 Free PMC article.

Truncated CD19 as a selection marker for the isolation of stem cell derived β-cells. Ting Helen Huang L, Gao RJ, Zhang D, Nian C, Martzke W, Shapiro AMJ, Kin T, Tahamtani Y, Lynn FC .Dis Model Mech. 2025 Oct 6:dmm.052376. doi: 10.1242/dmm.052376. Online ahead of print.PMID: 41048051 Free article.

Modeling Cystic Fibrosis Patient-Specific Responses to CFTR Modulators Using Human Induced Pluripotent Stem Cells. Kanagarajah KR, Wu MJM, Lam T, Quach HT, Salih R, Antonio K, Moraes TJ, Ratjen F, Bear CE, Wong AP. Am J Respir Crit Care Med. 2025 Oct;211(10):1970-1972. doi: 10.1164/rccm.202502-0467RL.PMID: 40548910 Free PMC article. No abstract available.

A potency and toxicology study on tolerability of cryopreserved mesenchymal stem cell product with DMSO in septic mice and nude rats. Wang Y, Hanover G, Murray ABP, Salkhordeh M, Tan Y, Wang C, Wang JP, McRae A, Deng Y, Florian M, Sahadevan P, Stewart DJ, Mclntyre L, Souza-Moreira L, Mei SHJ. Mol Ther Methods Clin Dev. 2025 Oct 6;33(4):101611. doi: 10.1016/j.omtm.2025.101611. eCollection 2025 Dec 11.PMID: 41210167 Free PMC article.